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Nervenheilkunde 2014; 33(05): 362-367
DOI: 10.1055/s-0038-1633407
Epilepsie
Schattauer GmbH

Ketogene Diät in der Therapie pharmakoresistenter Epilepsien

Indikationen und WirksamkeitKetogenic diet in the treatment of medically intractable epilepsiesIndications and efficacy
J. Kröll
1   Schweizerisches Epilepsie-Zentrum, Zürich
,
K. Otten
1   Schweizerisches Epilepsie-Zentrum, Zürich
,
M. Kurthen
1   Schweizerisches Epilepsie-Zentrum, Zürich
› Institutsangaben
Weitere Informationen

Publikationsverlauf

eingegangen am: 15. Januar 2014

angenommen am: 29. Januar 2014

Publikationsdatum:
02. Februar 2018 (online)

    Lizenzen und Reprints

Zusammenfassung

Die ketogene Diät (KD) ist eine seit mehr als hundert Jahren etablierte Therapie bei Kindern und Jugendlichen mit pharmakoresistenten Epilepsien. In den letzten Jahren hat das klinische Interesse an der KD durch Einführung weniger strenger und flexiblerer Therapieprotokolle wie der modifizierten Atkins-Diät (MAD) deutlich zugenommen. Aufgrund experimenteller Daten ergeben sich zunehmend Hinweise, dass die Wirksamkeit der Diät nicht auf eine antikonvulsive Wirkung beschränkt ist. Durch die Veränderung des zerebralen Energiestoffwechsels besitzt die KD auch ein mögliches neuroprotektives Potenzial, sodass im Rahmen wissenschaftlicher Studien zunehmend “neue” Indikationen der KD jenseits der Epilepsiebehandlung geprüft werden, z. B. der Einsatz bei neurodegenerativen Erkrankungen oder bei Hirntumoren.

Summary

For more than 100 years the ketogenic diet (KD) has been an established and well known treatment for children with pharmacoresistent epilepsies. During the last years the clinical interest in the ketogenic diet has significantly increased this due in part to the introduction of less strict and more flexible diet protocols like the modified Atkins diet (MAD). Experimental data also suggest that there is an additional potential impact beyond the diet’s anticonvulsive effect. Due to its influence on cerebral energy metabolism the KD probably possesses neuroprotective potential. This knowledge leading to an increasing number of clinical studies analyzing “new” indications, such as the treatment of neurodegenerative diseases or brain tumors.

Schlüsselwörter

Ketogene Diät - Indikationen - Effektivität - Nebenwirkungen - Wirkmechanismen

Keywords

Ketogenic diet - indications - efficacy - side-effects - modes of action
 

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