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Thromb Haemost 1973; 29(02): 347-352
DOI: 10.1055/s-0038-1647776
Original Article
Schattauer GmbH

Human Fibrinopeptides as Antithrombins

J. J Gorman
1   Haematology Department and Departments of Pathology and Medicine, Austin Hospital, University of Melbourne, Heidelburg, Victoria, 3084
,
P. A Castaldi
1   Haematology Department and Departments of Pathology and Medicine, Austin Hospital, University of Melbourne, Heidelburg, Victoria, 3084
› Author Affiliations
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Publication History

Received for publication 20 June 1972

Publication Date:
30 June 2018 (online)

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Summary

Human fibrinopeptides have been isolated from purified human fibrinogen and investigations performed on their reactions with thrombin and platelets. Fibrinopeptides A and B had an inhibitory action against the proteolytic action of thrombin but fibrinopeptide A did not impair the esterolytic activity of the enzyme. Studies on thrombin - catalysed platelet aggregation and C14-Serotonin release showed a similar inhibition but the fibrinopeptides had no effect on platelet reactivity with adenosine diphosphate or collagen. These properties of fibrinopeptides were demonstrated in concentrations compatible with a similar effect in localized thrombosis.

 

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