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Thromb Haemost 1996; 75(03): 466-470
DOI: 10.1055/s-0038-1650298
DOI: 10.1055/s-0038-1650298
Original Article
Identification and Biosynthesis of Fibrinogen in Human Uterine Cervix Carcinoma Cells
Further Information
Publication History
Received 11 September 1995
Accepted after revision 06 December 1995
Publication Date:
31 August 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/199603/lookinside/thumbnails/10-1055-s-0038-1650298-1.jpg)
Summary
Fibrinogen has been detected in ME-180 human uterine cervix carcinoma cells, and synthesis of fibrinogen by ME-180 cells has been measured using [35S] L-methionine incorporation. Expression of mRNA for the B|3-chain of the fibrinogen in ME-180 cells has been identified by PCR-assisted mRNA amplification. The AΑ-, BΒ-, and Γ-chains of fibrinogen synthesized by ME-180 cells were chemically and immunologically identical to those of plasma fibrinogen. These findings suggest that fibrinogen is present and synthesized in ME-180 human uterine cervix carcinoma cells, and that fibrinogen plays a role in these malignant tumor cells.
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