Initial Studies of a Potent Antiheparin Agent (Ubiquin®)

Summary

Ubiquin (oligo-3-(N-methylmorpholinium)-l,2-propylene oxide chloride) is a stable, water soluble, active heparin antagonist producing prompt neutralization when administered in a 1:1 ratio to rats and dogs. Initial studies indicate that it is devoid of any effect on coagulation per se; nor are there any obvious side effects manifested during the process of neutralization. The acute toxicity is less than that of other compounds in use: toluidine blue, protamine and hexadimethrine.

• References

• 1 Buddecke E. Exchange effect of the diffusion factor, oligo-N-methyl morpholinio propylene oxide, on anionic polysaccharides. Z. physiol. Chem 1962; 330: 84
• 2 Finney D.J. Statistical methods in biological assay. Haffrier Publ. Co.; 1964
• 3 Frimmer M. Growth inhibition of rats by oligo-N-methyl morpholinium propylene oxide. Klin. Wschr 1964; 42: 797
• 4 Kimura E.T, Young P.R, Stein B.J, Richards R.K. Some pharmacologic characteristics of hexadimethrine bromide (Polybrene) a new antiheparin agent. Toxic, appl. Pharmacol 1959; 1: 185
• 5 LeRoy G.V, Halpern B, Dolkart E. An indirect, quantitative method for the estimation of heparin activity in vitro : the heparin-protamine titration test. J. Lab. clin. Med 1950; 35: 446
• 6 Ollendorff B. The nature of the anticoagulant effect of heparin, protamine, Polybrene and toluidine blue. Scand. J. clin. Lab. Invest 1962; 14: 267
• 7 Preston W, Barker B. New antiheparin agent (“Polybrene”). Arch. Surg 1953; 66: 545
• 8 Weiss W.A, Gilman J.S, Catenacci A.J, Osterberg A.E. Heparin neutralization with Polybrene administered intravenously. J. A.M. A 1958; 166: 603