Download PDF
Thromb Haemost 1965; 14(03/04): 500-507
DOI: 10.1055/s-0038-1654886
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Activation of Fibrinolysis and of Plasma-Kinin System during Venostasis*

K Buluk
1   Department of General and Experimental Pathology Medical School, Bialystok, Poland (Head of Department: Prof. Dr. Karol Buluk)
,
M Malofiejew
1   Department of General and Experimental Pathology Medical School, Bialystok, Poland (Head of Department: Prof. Dr. Karol Buluk)
,
Maria Czokalo
1   Department of General and Experimental Pathology Medical School, Bialystok, Poland (Head of Department: Prof. Dr. Karol Buluk)
› Author AffiliationsThis investigation was supported by a grant from the Theme Panel “Pathogenesis of Shock” Section of Medical Sciences, Polish Academy of Sciences.
Further Information

Publication History

Publication Date:
24 July 2018 (online)

Also available at
    Permissions and Reprints

Summary

In the plasma of stasis blood, fibrinolytic activity increases as a result of the enrichment of this blood by fibrinolysis activators of tissue origin. With the increase in fibrinolytic activity an increase in kallikrein and a temporary release of plasma kinin occurs. Plasma kallikrein, activated in the stasis blood through fibrinolysis activation on application of a manometric cuff retains its activity and may play some role in the lowering of blood pressure when the cuff is removed.

 

  • References

  • 1 Allwood M. J, Lewis G. P. Bradykinin and forearm blood flow. J. Physiol. (Lond.) 170: 571 1964;
    CrossrefPubMedGoogle Scholar
  • 2 Back N, Guth P. S, Murson A. E. On the relationship between plasmin and kinin. Ann. N.Y. Acad. Sci. 204: 53 1963;
    PubMedGoogle Scholar
  • 3 Beraldo W. T. Formation of bradykinin in anaphylactic and peptone shock. Amer. J. Physiol. 163: 283 1950;
    PubMedGoogle Scholar
  • 4 Buluk K, Januszko T, Olbromski J, Chmielewski J. O aktywacji fibrynolizy. Pol. Arch. Med. Wewn. 32: 769 1962;
    PubMedGoogle Scholar
  • 5 Buluk K, Furman M. On the controlling function of the kidneys in fibrinolysis. Experientia. 18: 146 1962;
    CrossrefPubMedGoogle Scholar
  • 6 Buluk K, Malofiejew M. Preparation of fibrinolysis activator in the extracorporal kidney. Acta Physiol, pol. 14: 371 1963;
    PubMedGoogle Scholar
  • 7 Buluk K, Malofiejew M. Urokinase induced activation of kallikreinogen and the release of plasma kinins in renal blood. Acta med. pol. (In press.)
    PubMedGoogle Scholar
  • 8 Eisen V. Observations on intrinsic kinin-forming factors in human plasma: the effect of acid, acetone, chloroform, heat and euglobulin separation on kinin formation. J. Physiol. (Lond.) 166: 496 1963;
    CrossrefPubMedGoogle Scholar
  • 9 Furman M. Aktywacja fibrynolizy krwi krazacej krolika. Doctoral thesis. Bialystok; 1963
    Google Scholar
  • 10 Januszko T, Dubinska L. Pomiar aktywatora fibrynolizy w tescie euglobulinowym. Acta med. pol. 06: 269 1965;
    PubMedGoogle Scholar
  • 11 Kwaan H. C, Lo R, McFadzean AJS. The production of plasma fibrinolytic activity in vivo by serotonin (5-hydroxytryptamine) creatinine sulphate. Clin. Sci. 16: 241 1957;
    PubMedGoogle Scholar
  • 12 Lewis G. P. Formation of plasma kinins by plasmin. J. Physiol. (Lond.) 140: 285 1958;
    CrossrefPubMedGoogle Scholar
  • 13 Schächter M. A delayed slow-contracting effect of serum and plasma due to the release of a substance resembling kallidin and bradykinin. Brit. J. Pharmacol. 11: 111 1956;
    PubMedGoogle Scholar
  • 14 Vogt W. Kinin formation by plasmin, and indirect process mediated by activation of kallikrein. J. Phj^siol. (Lond.) 170: 153 1964;
    PubMedGoogle Scholar