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Thromb Haemost 1967; 05(03/04): 433-438
DOI: 10.1055/s-0038-1655052
Originalarbeiten — Original Articles — Travaux Originaux
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Fibrinolytic System in Hypotensive Patients; with a Special Reference to the Effect of Epsilon-Amino Caproic Acid (EACA)

A Gabryelewicz
1   Department of Physiological Chemistry (Head: Doc. S. Niewiarowslci, M. D) and Second Department of Medicine (Head: Prof. J. Chlebowski, M. D), Medical School, Białystok ( Poland)
,
S Niewiarowski
1   Department of Physiological Chemistry (Head: Doc. S. Niewiarowslci, M. D) and Second Department of Medicine (Head: Prof. J. Chlebowski, M. D), Medical School, Białystok ( Poland)
,
J Prokopowicz
1   Department of Physiological Chemistry (Head: Doc. S. Niewiarowslci, M. D) and Second Department of Medicine (Head: Prof. J. Chlebowski, M. D), Medical School, Białystok ( Poland)
,
K Worowski
1   Department of Physiological Chemistry (Head: Doc. S. Niewiarowslci, M. D) and Second Department of Medicine (Head: Prof. J. Chlebowski, M. D), Medical School, Białystok ( Poland)
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Publication History

Publication Date:
26 June 2018 (online)

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Summary

An acceleration of euglobulin fibrinolysis and a slight decrease of plasminogen and of antiplasmin were found in idiopathic hypotensive patients. EACA administered orally in daily doses 0.1 g /kg of weight for 4 days produced both an inhibition of fibrinolysis and a significant rise in arterial blood pressure in 15 of 18 patients studied. It has been suggested that the pressure effect of EACA may be mediated by inhibiting plasminogen activation.

 

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