Thromb Haemost 1985; 54(02): 558
DOI: 10.1055/s-0038-1657905
Letter to the Editor
Schattauer GmbH Stuttgart

Biological Properties of Recombinant and of Natural Pro-Urokinase

Victor Gurewich
Vascular Laboratory, Department of Biomedical Research, St. Elizabeth's Hospital, Tufts University School of Medicine, Boston, MA 02135, USA
,
Ralph Pannell
Vascular Laboratory, Department of Biomedical Research, St. Elizabeth's Hospital, Tufts University School of Medicine, Boston, MA 02135, USA
› Author Affiliations
Further Information

Publication History

Received 07 November 1984

Accepted 05 December 1984

Publication Date:
18 July 2018 (online)

 
  • References

  • 1 Husain SS, Lipinski B, Gurewich V. Isolation of plasminogen activators useful as therapeutic and diagnostic agents (single-chain, high-fibrin affinity urokinase). US Patent No. 4381346 (filed November 13, 1979; issued April 26, 1983).
  • 2 Husain SS, Gurewich V, Lipinski B. Purification of a new high molecular weight single chain form of urokinase from urine. Thromb Haemostas 1981; 46: 11 (Abstr)
  • 3 Husain SS, Gurewich V, Lipinski B. Purification and partial characterization of a single-chain, high molecular weight form of urokinase from human urine. Arch Biochem Biophys 1983; 220: 31-38
  • 4 Gurewich V, Pannell R. Fibrin-specificity and efficacy of proteolysis induced by single-chain urokinase (SC-UK) in plasma. Thromb Haemostas 1983; 50: 321 (Abstr)
  • 5 Gurewich V, Pannell R, Louie S, Kelley P, Suddith RL, Greenlee R. Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase). A study in vitro and in two animal species. J Clin Invest 1984; 73: 1731-1739
  • 6 Matsuo O, Mihara H. Threshold phenomena in blood fibrinolysis. Thromb Res 1977; 10: 753-758