Subscribe to RSS
DOI: 10.1055/s-0040-1710054
Quality of Life in Children with Epilepsy
Funding None.Publication History
23 February 2020
29 March 2020
Publication Date:
18 April 2020 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00029025/202002/lookinside/thumbnails/10-1055-s-0040-1710054_2000010-1.jpg)
Abstract
Objective The main aim of this study was to assess quality of life in children with epilepsy.
Materials and Methods A prospective observational study was conducted in Regional Early Intervention Centre of the Department of Pediatrics Tertiary Care Hospital in central India. This study included 120 children with epilepsy aged between 2 and 18 years. In this study, we assessed the quality of life in children with epilepsy with the help of Pediatric Quality of Life Inventory (PedsQL). We further analyzed the quality of life in various dimensions. For the statistical analyses for SPSS version, 20 was used, chi-squared and Fisher's exact test was used for categorical variables, and Student's t-test was used for quantitative variables. Linear regression analysis was done for multivariate analysis.
Result Mean total PedsQL score for total cohort was 70.96. The cognitive dimension of epileptic children was more affected than physical, social, and emotional dimensions. Factors associated with lower PedsQL scores in epilepsy patients were associated with long duration of epilepsy, polytherapy, male gender, low head circumference, presence of intellectual disability, and refractory epilepsy.
Conclusion Epilepsy affects the quality of life in children across all age groups. Among epilepsy indicators, polytherapy, refractory epilepsy, and duration of epilepsy were the most important factors associated with poor quality of life. We can conclude that every effort should be made to decrease the duration of treatment and minimize the number of drugs for improving the quality of life in this patient cohort.
Ethical Approval
This study received its ethical approval from the Institutional Ethics Committee of SS Medical College, under Project no. 24, in 2018.
Authors' Contribution
M.K.P. conceptualized and designed the scope of this study, and performed data collection. D.D. conceptualized and analyzed this study.
-
References
- 1 Panayiotopoulos CP. The new ILAE report on terminology and concepts for organization of epileptic seizures: a clinician's critical view and contribution. Epilepsia 2011; 52 (12) 2155-2160
- 2 Larsson K, Eeg-Olofsson O. A population based study of epilepsy in children from a Swedish county. Eur J Paediatr Neurol 2006; 10 (03) 107-113
- 3 Lv R, Wu L, Jin L. , et al. Depression, anxiety and quality of life in parents of children with epilepsy. Acta Neurol Scand 2009; 120 (05) 335-341
- 4 Sridharan R, Murthy BN. Prevalence and pattern of epilepsy in India. Epilepsia 1999; 40 (05) 631-636
- 5 Ronen GM, Streiner DL, Rosenbaum P. Health-related quality of life in childhood epilepsy: moving beyond 'seizure control with minimal adverse effects'. Health Qual Life Outcomes 2003; 1: 36
- 6 Krishnamoorthy ES, Trimble MR, Blumer D. The classification of neuropsychiatric disorders in epilepsy: a proposal by the ILAE Commission on Psychobiology of Epilepsy. Epilepsy Behav 2007; 10 (03) 349-353
- 7 Lach LM, Ronen GM, Rosenbaum PL. , et al. Health-related quality of life in youth with epilepsy: theoretical model for clinicians and researchers. Part I: the role of epilepsy and co-morbidity. Qual Life Res 2006; 15 (07) 1161-1171
- 8 Varni JW, Seid M, Kurtin PS. PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care 2001; 39 (08) 800-812
- 9 Shaikh Z, Pathak R. Revised Kuppuswamy and B G Prasad socio-economic scales for 2016. Int J Community Med Public Health. 2017; 4 (04) 997-999
- 10 Kwan P, Brodie MJ. Definition of refractory epilepsy: defining the indefinable?. Lancet Neurol 2010; 9 (01) 27-29
- 11 Roid GH, Pomplun M. The Stanford-Binet Intelligence Scales. 5th edition. In: Contemporary Intellectual Assessment: Theories, Tests, and Issues, 3rd ed. New York, NY, US: The Guilford Press; 2012: 249-268
- 12 Ovšonková A, Mahútová Z. The quality of life for children with epilepsy. Osetr Porod Asist 2014; 5: 9-14
- 13 Bansal D, Azad C, Gudala K, Dasari A. Predictors of health related quality of life in childhood epilepsy and comparison with healthy children: findings from an Indian study. Turk J Med Sci 2017; 47 (02) 490-498
- 14 Nadkarni J, Jain A, Dwivedi R. Quality of life in children with epilepsy. Ann Indian Acad Neurol 2011; 14 (04) 279-282
- 15 Nagabushana D, , S PK, Agadi JB. Impact of epilepsy and antiepileptic drugs on health and quality of life in Indian children. Epilepsy Behav 2019; 93: 43-48
- 16 Aggarwal A, Datta V, Thakur LC. Quality of life in children with epilepsy. Indian Pediatr 2011; 48 (11) 893-896
- 17 Puka K, Tavares TP, Anderson KK, Ferro MA, Speechley KN. A systematic review of quality of life in parents of children with epilepsy. Epilepsy Behav 2018; 82: 38-45
- 18 Arya V, Gehlawat VK, Kaushik JS, Gathwala G. Assessment of parent reported quality of life in children with epilepsy from Northern India: a cross-sectional study. J Pediatr Neurosci 2014; 9 (01) 17-20
- 19 Sokka A, Olsen P, Kirjavainen J. , et al. Etiology, syndrome diagnosis, and cognition in childhood-onset epilepsy: a population-based study. Epilepsia Open 2017; 2 (01) 76-83
- 20 Liu X, Han Q. Risk factors on health-related quality of life in children with epilepsy. Clin Pediatr (Phila) 2015; 54 (14) 1334-1338
- 21 Perrine K, Hermann BP, Meador KJ. , et al. The relationship of neuropsychological functioning to quality of life in epilepsy. Arch Neurol 1995; 52 (10) 997-1003
- 22 Fong CY, Chang WM, Kong AN, Rithauddin AM, Khoo TB, Ong LC. Quality of life in Malaysian children with epilepsy. Epilepsy Behav 2018; 80: 15-20
- 23 Malhi P, Singhi P. Correlates of quality of life with epilepsy. Indian J Pediatr 2005; 72 (02) 131-135
- 24 Radović NI, Božić K, Đurić AP, Vodopić S, Radulović L, Vujisić S. Health-related quality of life in adolescents with epilepsy in Montenegro. Epilepsy Behav 2017; 76: 105-109
- 25 Fisher RS, Nune G, Roberts SE, Cramer JA. The personal impact of epilepsy scale (PIES). Epilepsy Behav 2015; 42: 140-146