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Am J Perinatol 2024; 41(04): 422-428
DOI: 10.1055/s-0041-1740299
Original Article

Parental Height and Weight Influence Offspring Adiposity at 2 Years; Findings from the ROLO Kids Birth Cohort Study

Jean M. Donnelly
1   University College Dublin, Perinatal Research Centre, School of Medicine, Department of Obstetrics and Gynecology, University College Dublin, National Maternity Hospital, Dublin, Ireland
2   Department of Neonatology Our Lady's Children's Hospital Crumlin, Ireland
,
Jennifer M. Walsh
1   University College Dublin, Perinatal Research Centre, School of Medicine, Department of Obstetrics and Gynecology, University College Dublin, National Maternity Hospital, Dublin, Ireland
,
Mary K. Horan
1   University College Dublin, Perinatal Research Centre, School of Medicine, Department of Obstetrics and Gynecology, University College Dublin, National Maternity Hospital, Dublin, Ireland
,
John Mehegan
3   University College Dublin, School of Public Health, Physiotherapy and Sports Science, Dublin, Ireland
,
Eleanor J. Molloy
2   Department of Neonatology Our Lady's Children's Hospital Crumlin, Ireland
4   Department of Paediatrics, University of Dublin, Dublin, Ireland
5   Department of Neonatology, Coombe Women and Infants Hospital, Dublin, Ireland
,
David F. Byrne
1   University College Dublin, Perinatal Research Centre, School of Medicine, Department of Obstetrics and Gynecology, University College Dublin, National Maternity Hospital, Dublin, Ireland
,
Fionnuala M. McAuliffe
1   University College Dublin, Perinatal Research Centre, School of Medicine, Department of Obstetrics and Gynecology, University College Dublin, National Maternity Hospital, Dublin, Ireland
› Institutsangaben Funding Health Research Board Ireland Health Research Centre for Diet and Health Research, The National Maternity Hospital Medical Fund, and The European Union's Seventh Framework Programme (FP7/2007-2013) project Early Nutrition under grant agreement no. 289346 supported this research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Abstract

Objective The perinatal period and in utero environment are important for fetal growth, development, and fetal programming. This study aimed to determine the effect of parental anthropometry and the maternal metabolic milieu on offspring adiposity at 2 years of age.

Study Design This longitudinal birth cohort includes analysis of maternal (n = 337) and paternal (n = 219) anthropometry and maternal and fetal metabolic markers (n = 337), including glucose, homeostatic model of assessment (HOMA), C-peptide, and leptin from participants of the ROLO (the Randomized Control Trial of Low) pregnancy study, and their partners, to determine an association with offspring anthropometry at two years of age.

Results Linear regression, when adjusted for confounders, indicated maternal and paternal anthropometry and was associated with offspring weight and length at 2 years of age. Maternal height was negatively associated with general adiposity in the total cohort of children (p = 0.002) and in female children (p = 0.006) and central adiposity in the total child cohort (p < 0.001). Paternal height was also negatively associated with general adiposity in all children (p = 0.002) and central adiposity in total (p = 0.023) and female children (p = 0.008). Maternal glucose, insulin resistance, and fetal C-peptide positively correlated with anthropometry in total, male, and female children.

Conclusion Parental anthropometry in the perinatal period has a long-lasting effect on offspring anthropometry beyond the neonatal period. Maternal and fetal metabolic factors influence adiposity, and this extends beyond the perinatal period. Parental adiposity may play a significant role in early childhood adiposity and may be a target for interventions to decrease the risk of early childhood obesity.

Key Points

  • Parental height and weight were associated with offspring anthropometry and measures of offspring adiposity at 2 years of age.

  • Maternal glucose, insulin resistance, and fetal C-peptide correlated with offspring anthropometry.

  • Parental anthropometry has long-term effect on offspring adiposity and is seen at 2 years of age.

Keywords

maternal anthropometry - paternal anthropometry - adiposity - follow-up study

Supplementary Material



Publikationsverlauf

Eingereicht: 14. April 2021

Angenommen: 24. Oktober 2021

Artikel online veröffentlicht:
29. Dezember 2021

© 2021. Thieme. All rights reserved.

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333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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