Intensivmedizin up2date 2016; 12(03): 251-263
DOI: 10.1055/s-0042-105596
Allgemeine Prinzipien der Intensivmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Der schwierig zu weanende Patient

Johannes Bickenbach
Further Information

Publication History

Publication Date:
11 August 2016 (online)

Kernaussagen
  • Das frühzeitige Erkennen einer akuten respiratorischen Insuffizienz sowie die Behandlung der Ursache sind essenziell, weil sich daraus unterschiedliche Folgerungen für die Beatmungstherapie und die Beatmungsentwöhnung ergeben.

  • Die maschinelle Beatmung ist einer der wesentlichen Grundpfeiler der Intensivmedizin und dient der Behandlung der akuten respiratorischen Insuffizienz. Gerade die invasive maschinelle Beatmung ist mit substanziellen Risiken verbunden und sollte so rasch wie möglich wieder beendet werden.

  • So bald als möglich muss man die Spontanatmungsaktivität des Patienten überprüfen.

  • Weaning-Protokolle, aber vor allem gebündelte Strategien können helfen, den Prozess des Weanings zu lenken. Hierzu zählen auch die patientengesteuerte Beatmungsunterstützung, eine frühzeitige Tracheotomie und die nicht invasive Beatmung.

  • Das prolongierte Weaning ist vor allem von der ausgeprägten muskulären Schwäche geprägt. Die muskuläre Rehabilitation ist aufwendig und erfordert systematische physiotherapeutische und logopädische Maßnahmen.

  • Substanzielle Begleiterkrankungen wie die Herzinsuffizienz muss man differenzialdiagnostisch berücksichtigen.

  • Die Indikation zur außerklinischen Beatmung sollte nur ein spezialisiertes Weaning-Zentrum stellen. Die Überleitung ist komplex und erfordert ein erfahrenes Behandlungsteam.

 
  • Literatur

  • 1 Zilberberg MD, de Wit M, Pirone JR et al. Growth in adult prolonged acute mechanical ventilation: Implications for healthcare delivery. Crit Care Med 2008; 36: 1451-1455
  • 2 Halbertsma FJ, Vaneker M, Scheffer GJ et al. Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature. Neth J Med 2005; 63: 382-392
  • 3 Silva PL, Negrini D, Macêdo Rocco PR. Mechanisms of ventilator-induced lung injury in healthy lungs. Best Pract Res Clin Anaesthesiol 2015; 29: 301-313
  • 4 Hunter JD. Ventilator associated pneumonia. Postgrad Med J 2006; 82: 172-178
  • 5 Jaber S, Petrof BJ, Jung B et al. Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med 2011; 183: 364-371
  • 6 Levine S, Nguyen T, Taylor N et al. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 2008; 358: 1327-1335
  • 7 Hudson MB, Smuder AJ, Nelson WB et al. Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy. Crit Care Med 2012; 40: 1254-1260
  • 8 McClung JM, Van GD, Whidden MA et al. Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation. Crit Care Med 2009; 37: 1373-1379
  • 9 Shanely RA, Zergeroglu MA, Lennon SL et al. Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am J Respir Crit Care Med 2002; 166: 1369-1374
  • 10 Deruisseau KC, Kavazis AN, Deering MA et al. Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm. J Appl Physiol 2005; 98: 1314-1321
  • 11 Maes K, Testelmans D, Powers S et al. Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats. Am J Respir Crit Care Med 2007; 175: 1134-1138
  • 12 McClung JM, Kavazis AN, Deruisseau KC et al. Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy. Am J Respir Crit Care Med 2007; 175: 150-159
  • 13 Boles JM, Bion J, Connors A et al. Weaning from mechanical ventilation. Eur Respir J 2007; 29: 1033-1056
  • 14 Schönhofer B, Geiseler J, Dellweg D et al. S2k-guideline published by the German Respiratory Society. Pneumologie 2014; 68: 19-75
  • 15 Boulain T. Unplanned extubations in the adult intensive care unit: a prospective multicenter study. Association des Reanimateurs du Centre-Ouest. Am J Respir Crit Care Med 1998; 157: 1131-1137
  • 16 Fontenot AM, Malizia RA, Chopko MS et al. Revisiting endotracheal self-extubation in the surgical and trauma intensive care unit: Are they all fine?. J Crit Care 2015; pii: S0883-9441(15)00380-9 DOI: 10.1016/j.jcrc.2015.07.013.
  • 17 Im Internet: http://www.awmf.org/uploads/tx_szleitlinien/001012l_S3_Analgesie_Sedierung_Delirmanagement_Intensivmedizin_2015-08_01.pdf
  • 18 Ely EW, Margolin R, Francis J et al. Evaluation of delirium in critically ill patients: validation oft he Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med 2001; 29: 1370-1379
  • 19 Ladeira MT, Vital FM, Andriolo RB et al. Pressure support versus T-tube for weaning from mechanical ventilation in adults. Cochrane Database Syst Rev 2014; 5 CD006056.pub2 DOI: 10.1002/14651858.
  • 20 Goldstone J. The pulmonary physician in critical care. 10: difficult weaning. Thorax 2002; 57: 986-991
  • 21 Marelich GP, Murin S, Battistella F et al. Protocol weaning of mechanical ventilation in medical and surgical patients by respiratory care practitioners and nurses: effect on weaning time and incidence of ventilator-associated pneumonia. Chest 2000; 118: 459-467
  • 22 Gupta P, Giehler K, Walters RW et al. The Effect of a Mechanical Ventilation Discontinuation Protocol in Patients with Simple and Difficult Weaning: Impact on Clinical Outcomes. Respir Care 2014; 59: 170-177
  • 23 Yang KL, Tobin MJ. A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. N Engl J Med 1991; 324: 1445-1450
  • 24 Nemer SN, Barbas CS, Caldeira JB et al. A new integrative weaning index of discontinuation from mechanical ventilation. Crit Care 2009; 13: R152
  • 25 El-Baradey GF, El-Shmaa NS, Ganna SA. Can integrative weaning index be a routine predictor for weaning success?. Indian J Crit Care Med 2015; 19: 703-707
  • 26 Lellouche F, Mancebo J, Jolliet P et al. A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation. Am J Respir Crit Care Med 2006; 174: 894-900
  • 27 Burns KE, Meade MO, Lessard MR et al. Wean earlier and automatically with new technology (the WEAN study). A multicenter, pilot randomized controlled trial. Am J Respir Crit Care Med 2013; 187: 1203-1211
  • 28 Taniguchi C, Victor ES, Pieri T et al. Smart Care™ versus respiratory physiotherapy-driven manual weaning for critically ill adult patients: a randomized controlled trial. Crit Care 2015; 19: 246
  • 29 Blackwood B, Burns KE, Cardwell CR et al. Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients. Cochrane Database Syst Rev 2014; 11 CD006904
  • 30 Murias G, Villagra A, Blanch L. Patient-ventilator dyssynchrony during assisted invasive mechanical ventilation. Minerva Anestesiol 2013; 79: 434-444
  • 31 Clavieras N, Wysocki M, Coisel Y et al. Prospective Randomized Crossover Study of a New Closed-loop Control System versus Pressure Support during Weaning from Mechanical Ventilation. Anesthesiology 2013; 119: 631-641
  • 32 Ranieri M. Effects of proportional assist ventilation on inspiratory muscle effort in patients with chronic obstructive pulmonary disease and acute respiratory failure. Anesthesiology 1997; 86: 79-91
  • 33 Di Mussi R, Spadaro S, Mirabella L et al. Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV. Crit Care 2016; 20: 1
  • 34 Li Bassi G, Luque N, Martí JD et al. Endotracheal tubes for critically ill patients: an in vivo analysis of associated tracheal injury, mucociliary clearance, and sealing efficacy. Chest 2015; 147: 1327-1335
  • 35 Bickenbach J, Fries M, Offermanns V et al. Impact of early vs. late tracheostomy on weaning: a retrospective analysis. Minerva Anestesiol 2011; 77: 1176-1183
  • 36 Hosokawa K, Nishimura M, Egi M et al. Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials. Crit Care 2015; 19: 424
  • 37 Vargas M, Sutherasan Y, Antonelli M et al. Tracheostomy procedures in the intensive care unit: an international survey. Crit Care 2015; 19: 291
  • 38 Ferrer M, Esquinas A, Arancibia F et al. Noninvasive ventilation during persistent weaning failure: a randomized controlled trial. Am J Respir Crit Care Med 2003; 168: 70-76
  • 39 Girault C, Daudenthun I, Chevron V et al. Noninvasive ventilation as a systematic extubation and weaning technique in acute-on-chronic respiratory failure: a prospective, randomized controlled study. Am J Respir Crit Care Med 1999; 160: 86-92
  • 40 Ferrer M, Sellarés J, Valencia M et al. Non-invasive ventilation after extubation in hypercapnic patients with chronic respiratory disorders: randomised controlled trial. Lancet 2009; 374: 1082-1088
  • 41 Ferrer M, Sellares J, Torres A. Noninvasive ventilation in withdrawal from mechanical ventilation. Semin Respir Crit Care Med 2014; 35: 507-518
  • 42 Im Internet: http://www.awmf.org/leitlinien/detail/ll/020-004.html
  • 43 Vincent JL, Marshall JC, Namendys-Silva SA et al. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir Med 2014; 2: 380-386
  • 44 Dos Santos LJ, de Aguiar Lemos F, Bianchi T et al. Early rehabilitation using a passive cycle ergometer on muscle morphology in mechanically ventilated critically ill patients in the Intensive Care Unit (MoVe-ICU study): study protocol for a randomized controlled trial. Trials 2015; 16: 383
  • 45 Mehrholz J, Mückel S, Oehmichen F et al. First results about recovery of walking function in patients with intensive care unit-acquired muscle weakness from the General Weakness Syndrome Therapy (GymNAST) cohort study. BMJ Open 2015; 5: e008828
  • 46 Hill GL. Impact of nutritional support on the clinical outcome of the surgical patient. Clin Nutr 1994; 13: 331-340
  • 47 Alsumrain MH, Jawad SA, Imran NB et al. Association of hypophosphatemia with failure-to-wean from mechanical ventilation. Ann Cli Lab Sci 2010; 40: 144-148
  • 48 Frutos-Vivar F, Ferguson ND, Esteban A et al. Risk factors for extubation failure in patients following a successful spontaneous breathing trial. Chest 2006; 130: 1664-1671
  • 49 Pinsky MR. The hemodynamic consequences of mechanical ventilation: an evolving story. Intensive Care Med 1997; 23: 493-503
  • 50 Querschnitts-Leitlinien (BÄK) zur Therapie mit Blutkomponenten und Plasmaderivaten. 2014 4. Auflage. Im Internet: http://www.bundesaerztekammer.de/downloads/QLL_Haemotherapie_2014.pdf
  • 51 Schönhofer B, Wenzel M, Geibel M et al. Blood transfusion and lung function in chronically anemic patients with severe chronic obstructive pulmonary disease. Crit Care Med 1998; 26: 1824-1828
  • 52 Schönhofer B, Böhrer H, Köhler D. Blood transfusion facilitating difficult weaning from the ventilator. Anaesthesia 1998; 53: 181-184