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Clin Colon Rectal Surg 2024; 37(03): 140-145
DOI: 10.1055/s-0043-1770382
Review Article

Colorectal Cancer Risk between Mendelian and Non-Mendelian Inheritance

Elizabeth A. Hibler
1   Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
,
Brittany Szymaniak
2   Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
,
Mohammad Ali Abbass
3   Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
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Abstract

Hereditary colorectal cancer has been an area of focus for research and public health practitioners due to our ability to quantify risk and then act based on such results by enrolling patients in surveillance programs. The wide access to genetic testing and whole-genome sequencing has resulted in identifying many low/moderate penetrance genes. Above all, our understanding of the family component of colorectal cancer has been improving. Polygenic scores are becoming part of the risk assessment for many cancers, and the data about polygenic risk scores for colorectal cancer is promising. The challenge is determining how we incorporate this data in clinical care.

Keywords

cancer - inherited - polygenic - penetrance - Mendelian


Publication History

Article published online:
31 July 2023

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