Synthesis of Methoxy Analogues of Coenzyme Q₁₀ Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes

Abstract

Based on the parsley seed main component, apiol, efficient approach to polymethoxyquinone C₃- and C₄-acids was developed. The key step of this approach is Baeyer–Villiger rearrangement of carbonyl-substituted polyalkoxybenzenes derived from parsley seed extracts. These acids are the MeO-analogues of natural antioxidants – metabolites of ubiquinone and idebenone. Due to antioxidant properties, they are the potential therapeutic candidates for the treatment of mitochondrial dysfunction.

Key words

parsley - apiol - Baeyer–Villiger rearrangement - polymethoxyquinone acids - coenzyme Q₁₀ - antioxidants

Publication History

Received: 20 February 2024

Accepted after revision: 16 May 2024

Article published online:
18 June 2024

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