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J Pediatr Infect Dis 2024; 19(06): 339-344
DOI: 10.1055/s-0044-1791802
Original Article

Evaluation of a Risk Model for Sepsis Early Prediction in Infants with Epidermolysis Bullosa

Shuyan Zhang
1   Department of Pediatrics, Affiliated Hospital of Hebei Engineering University, Handan, China
,
Jing Wang
2   Department of Internal Medicine-Neurology, Affiliated Hospital of Hebei Engineering University, Handan, China
,
Lingyu Li
3   Department of Dermatology, Affiliated Hospital of Hebei Engineering University, Handan, China
,
Liyan Jiao
3   Department of Dermatology, Affiliated Hospital of Hebei Engineering University, Handan, China
,
Xiaojuan Liu
3   Department of Dermatology, Affiliated Hospital of Hebei Engineering University, Handan, China
,
Lili Ping
4   Department of Neonatology, Handan Central Hospital, Handan, China
› Author Affiliations Funding Application of clinical nursing pathway in infants with epidermolysis bullosa (20200208).
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Abstract

Objective Epidermolysis bullosa (EB) is a severe hereditary condition characterized by fragile skin that can lead to complications, including severe infections such as sepsis. Current research on sepsis in children with EB is limited, and there is a need for specific biomarkers that can aid in early detection and management.

Methods This study analyzed blood samples from 92 children diagnosed with EB, 42 of whom developed sepsis. We investigated various inflammatory proteins and clinical parameters as potential biomarkers. Multivariate analysis was used to determine predictors of sepsis occurrence.

Results Elevated levels of C-reactive protein (CRP), interleukin-6 (IL-6), lactate, and decreased oxygen saturation were significantly associated with sepsis in children with EB. The predictive model displayed an area under the receiver operating characteristic curve of 0.80 in the training set and 0.77 in the validation set, indicating good predictive accuracy.

Conclusion Our findings suggest that CRP, IL-6, lactate, and oxygen saturation are reliable predictors of sepsis in children with EB. These biomarkers should be monitored closely to facilitate early diagnosis and improve outcomes in this vulnerable population. The study underscores the need for tailored research and diagnostic strategies for children with EB at risk of sepsis.

Keywords

epidermolysis bullosa - sepsis - biomarkers - pediatric infectious disease - inflammatory proteins

Supplementary Material



Publication History

Received: 06 May 2024

Accepted: 18 September 2024

Article published online:
18 October 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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