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Digestive Disease Interventions
DOI: 10.1055/s-0045-1804916
Review Article

Updates in IPMN Surveillance following Resection: A Review Article

Jon M. Harrison
1   Section of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, Stanford University Hospital, Palo Alto, California
,
Motaz Qadan
2   Division of GI and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts
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Abstract

Surveillance strategies following resection for intraductal papillary mucinous neoplasms (IPMNs) are heterogeneously described. Understanding patterns of recurrences, risk factors for recurrences, and mechanisms by which recurrences occur is important for informing contemporary management. This review incorporates nearly 25 years of IPMN experience to emphasize noninvasive IPMN outcomes, categorize risk factors that contribute to recurrence, and, most importantly, describe overall recurrence risks. Aggregated, the rates for overall recurrence rate, remnant recurrence, invasive cancer, and invasive cancer within the pancreatic remnant are 9, 7, 2, and 1%, respectively, with a median time-to-recurrence of 33 months. These results provide a surveillance framework for capturing and intervening on most clinically relevant recurrences.

Keywords

intraductal papillary mutinous neoplasm - post-pancreatectomy IPMN surveillance - noninvasive IPMN - IPMN high-grade dysplasia - invasive carcinoma


Publication History

Received: 25 August 2024

Accepted: 28 January 2025

Article published online:
03 March 2025

© 2025. Thieme. All rights reserved.

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