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Synthesis 1986; 1986(8): 668-670
DOI: 10.1055/s-1986-31743
communication
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Convenient Syntheses of Pyrimidino[4,5-b][1,5]benzodiazepinones and Pyrimidino[1,6-a]benzimidazolones

Tomoji Aotsuka* , Hikari Morita, Kaname Takagi, Yoshihisa Okamoto
  • *Central Research Laboratories, Zeria Pharmaceutical Co., Konanmachi, Osato-gun, Saitama 360-01, Japan
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Publication Date:
22 August 2002 (online)

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Pyrimidino[4,5-b][1,5]benzodiazepinones 4 and pyrimidino [1,6-a]benzimidazolones 5 were synthesized from 4-ethoxycarbonylamino-1H-1,5-benzodiazepine-3-carbonitrile (2) via ring transformation with some aliphatic primary amines. The reaction mechanisms for the formation of these compounds are proposed.