Synthesis 1988; 1988(3): 233-234
DOI: 10.1055/s-1988-27525
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An Improved Procedure for the Preparation of Acetals from Diaryl Ketones

Andrew Thurkauf* , Arthur E. Jacobson, Kenner C. Riee
  • *Section on Drug Design and Synthesis, Laboratory of Neuroscience, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
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Publication History

Publication Date:
20 August 2002 (online)

Acetals of diaryl ketones with nitro, halo and methoxy substituents are easily prepared in high yield by treatment with an alcohol and the corresponding trialkyl orthoformate in the presence of a catalytic amount of trifluoromethanesulfonic acid.