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Synthesis 1989; 1989(8): 638-641
DOI: 10.1055/s-1989-27346
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A Novel Convenient Synthesis of 8-Oxo-3-thioxo-2,3,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazines

Kee-Jung Lee* , Seongkon Kim, Hyunsuk Um, Hokoon Park
  • *Organic Chemistry Laboratory III, Korea Advanced Institute of Science and Technology, P.O. Box 131 Cheongryang, Seoul, Korea
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Publikationsdatum:
17. September 2002 (online)

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A novel method for the synthesis of 8-oxo-3-thioxo-2,3,7,8-tetrahydro- 1,2,4-triazolo[4,3-a]pyrazines 3 consists of an intramolecular condensation reaction of substituted 1,2,4-triazoline-3-thiones 9, which possess acetal and aminocarbonyl moieties, with 5% hydrochloric acid. This method is convenient by virtue of its simplicity and the good yields.