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Synthesis 1991; 1991(11): 942-946
DOI: 10.1055/s-1991-26613
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Polycyclic N-Hetero Compounds. XLII: Convenient Syntheses of 6, 7-Dihydro-5H-pyrido[2,3-b]pyrimido[4,5-d]azepine as a Novel Polyheterocyclic Ring System and Its 4-Substituted Derivatives

Tomohisa Nagamatsu* , Yoshiji Hantani, Mikiko Takaishi, Kenji Sasaki, Takashi Hirota
  • *Faculty of Pharmaceutical Sciences, Okayama University, Tsushima 700, Japan
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Publication Date:
29 April 2002 (online)

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A convenient synthetic route for the syntheses of 6,7-dihydro-5H-pyrido[2, 3-b]pyrimido[4,5-d]azepine and its 4-substituted derivatives starting from ethyl 2-aminopyridine-3-carboxylate is described as the fist example of the unknown ring system. A new class of anti-platelet aggregation activity for them against collagene-induced aggregation of rabbit blood platelet in vitro was found.