Download PDF
Synthesis 1991; 1991(11): 947-950
DOI: 10.1055/s-1991-26614
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of 1-(Phosphonomethoxyalkoxy)pyrimidines, a Novel Series of Acyclonucleotide Analogues

Michael R. Harnden* , L. John Jennings, Ann Parkin
  • *SmithKline Beecham Pharmaceuticals, Yew Tree Bottom Road, Epsom, Surrey KT18 5XQ, England
Further Information

Publication History

Publication Date:
29 April 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A convenient synthesis of 1-(2-phosphonomethoxyalkoxy)uracil and -thymine derivatives, 4-7 by Mitsunobu coupling of 1-hydroxypyrimidines with suitably functionalized alcohols is described. The uracil analogues were converted to the corresponding 1-(phosphonomethoxyalkoxy)cytosines 8,9 via intermediate 4-(1,2,4-triazol-1-yl) derivatives. The antiviral activity of this series of compounds is reported.