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Synthesis 1992; 1992(3): 283-284
DOI: 10.1055/s-1992-26092
DOI: 10.1055/s-1992-26092
short paper
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An Efficient, Large-Scale Synthesis of 4,4-Dichloro-3-buten-2-one
Further Information
Publication History
Publication Date:
17 September 2002 (online)
The Friedel-Crafts condensation of acetyl chloride and vinylidene chloride (1,1-dichloroethylene) in dichloromethane solution gives 4,4,4-trichloro-2-butanone (2), which is smoothly dehydrohalogenated with triethylamine to produce 4,4-dichloro-3-buten-2-one (1) in excellent yield.