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Synthesis 1992; 1992(7): 641-642
DOI: 10.1055/s-1992-26185
DOI: 10.1055/s-1992-26185
short paper
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A Convenient One-Step Method of Converting Electron-Rich Aromatic Aldehydes into Nitriles
Further Information
Publication History
Publication Date:
17 September 2002 (online)
Electron-rich aromatic aldehydes react with sodium azide in the presence of aluminum chloride in boiling tetrahydrofuran to give the corresponding nitriles in good yields, while electron-deficient or hindered aromatic aldehydes lead to (diazidomethyl)arenes in moderate yield under similar conditions.