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Synthesis 1992; 1992(8): 773-778
DOI: 10.1055/s-1992-26224
DOI: 10.1055/s-1992-26224
paper
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New 2′-C-Branched-Chain Sugar Nucleoside Analogs with Potential Antiviral or Antitumor Activity
Further Information
Publication History
Publication Date:
17 September 2002 (online)
The synthesis of 2′-C-hydroxymethyl and 2′-C-methyl nucleoside analogs [1-(3-deoxy-2-hydroxymethyl-D-erythro-pentofuranosyl)-thymine (14), the corresponding adenine derivative. 17, 1-(2-methyl-β-D-ribofuranosyl)thymine (20) and 2′-methyladenosine (23)] by coupling of sugar moieties, easily prepared from α-D-isosaccharino-and α-D-glucosaccharino-1,4-lactone derivatives, respectively, with silylated thymine or 6-chloropurine is reported.
