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Synthesis 1993; 1993(1): 99-102
DOI: 10.1055/s-1993-25808
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A Novel Synthesis of 4-Hydroxy-3-phenylcoumarins by Titanium(III)-Mediated Reductive C-C Bond Formation

Angelo Clerici* , Ombretta Porta
  • *Dipartimento di Chimica del Politecnico, Pza L. da Vinci 32, I-20133 Milano, Italy
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Publication Date:
17 September 2002 (online)

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4-Hydroxy-3-phenylcoumarins (4-hydroxy-3-phenyl-2H-1-benzopyran-2-ones) were readily synthesized in two steps by the titanium(III)-mediated reaction of methyl benzoylformate and substituted salicylaldehydes followed by lactonization, under acidic conditions, of the resulting methyl 2,3-dihydroxy-3-(2-hydroxyaryl)-2-phenylpronanoates.