Synthesis 1993; 1993(2): 216-220
DOI: 10.1055/s-1993-25834
paper
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Enantioselective and Diastereoselective Formation of syn-3-Hydroxy-4-amino Acids (syn-Statines) via Tetramic Acids

Ulrich Schmidt* , Bernd Riedl, Gerhard Haas, Helmut Griesser, Andrea Vetter, Steffen Weinbrenner
  • *Institut für Organische Chemie und Isotopenforschung der Universität Stuttgart, Pfaffenwaldring 55, D-7000 Stuttgart 80, Germany
Further Information

Publication History

Publication Date:
17 September 2002 (online)

Enantiomerically pure pyrrolidine-2,4-diones (tetramic acids) which can be diastereoselectively hydrogenated to syn-statines (4-amino-3-hydroxy-6-methylheptanoic acids) have been prepared by catalytic hydrogenation of 4-(benzyloxycarbonylamino)-3-oxocarboxylic acid esters.