Download PDF
Synthesis 1994; 1994(4): 391-395
DOI: 10.1055/s-1994-25484
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

General and Versatile Approach to the Synthesis of Optically Active 5- Alkylpiperazine-2-carboxylic Acids

Massimo Falorni* , Giampaolo Giacomelli, Michele Satta, Sergio Cossu
  • *Dipartimento di Chimica, Università di Sassari, Via Vienna 2, I-07100 Sassari, Italy
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

General and convenient syntheses of optically active 5-alkylpiperazine-2-carboxylic acids are described. The methods are based on cyclization of L- or D-serine with α-amino acids and occur without loss of optical purity. The presented procedures are based on readily available starting materials and can be arranged for multigram quantities.