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Synthesis 1994; 1994(12): 1294-1300
DOI: 10.1055/s-1994-25684
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An Asymmetric Synthesis of (-)-Tetrahydrolipstatin

Agnès Pommier* , Jean-Marc Pons, Philip J. Kocienski, Loretta Wong
  • *Laboratoire de Synthèse Organique, URA CNRS 1411, Centre de St Jérome, boite D12, 13397 Marseille Cedex 20, France
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Publication Date:
25 April 2002 (online)

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A key step in a short asymmetric synthesis of the potent pancreatic lipase inhibitor (-)-tetrahydrolipstatin (2) is a Lewis acid-catalysed [2+2] cycloaddition of n-hexyl(trimethylsilyl)ketene (5) to (R) -3-(tert-butyldimethylsilyloxy)tetradecanal (4a).