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Synthesis 1995; 1995(11): 1362-1364
DOI: 10.1055/s-1995-4108
short paper
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Metallation of 2(1H)-Quinolinone: Synthesis of 3-Substituted Compounds

M. Fernández, E.de la Cuesta, C. Avendaño*
  • *Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, E-28040 Madrid, Spain, Fax +34(1)3941822
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Publication Date:
31 December 2000 (online)

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The ortho-directing effect of the amide function in the regioselective lithiation of 2(1H)-quinolinone has been confirmed. Direct or indirect electrophilic substitution may compete with previous multistep procedures to obtain 3-substituted compounds.

Regioselective substitution of 2(1H)-quinolinone from metallated species