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Synthesis 1996; 1996(8): 913-926
DOI: 10.1055/s-1996-4332
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1-Amino- and 1-Amidoalkyl Radicals: Generation and Stereoselective Reactions

Philippe Renaud* , Luc Giraud
  • *Université de Fribourg, Institut de Chimie Organique, Pérolles, CH-1700 Fribourg, Switzerland, Fax +41(37)299739; E-mail philippe.renaud@unifr.ch
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Publication Date:
31 December 2000 (online)

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Radical reactions have become, during the last fifteen years, a very important and useful alternative to ionic and pericyclic processes. 1-Amino- and 1-amidoalkyl radicals have attracted the interest of synthetic organic chemists for the synthesis of a wide range of nitrogen-containing products for the synthesis of a wide range of nitrogen-containing products of biological interest such as alkaloids, amino acids and peptides. The different ways of generating such radicals is presented, followed by a discussion of the stereoselectivity of their reactions. Finally, applications in the field of EPC synthesis using chiral auxiliary or chiral templates are displayed.

radicals - amines - stereoselectivity - EPC-synthesis