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DOI: 10.1055/s-1996-4332
1-Amino- and 1-Amidoalkyl Radicals: Generation and Stereoselective Reactions
Publication History
Publication Date:
31 December 2000 (online)
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Radical reactions have become, during the last fifteen years, a very important and useful alternative to ionic and pericyclic processes. 1-Amino- and 1-amidoalkyl radicals have attracted the interest of synthetic organic chemists for the synthesis of a wide range of nitrogen-containing products for the synthesis of a wide range of nitrogen-containing products of biological interest such as alkaloids, amino acids and peptides. The different ways of generating such radicals is presented, followed by a discussion of the stereoselectivity of their reactions. Finally, applications in the field of EPC synthesis using chiral auxiliary or chiral templates are displayed.
radicals - amines - stereoselectivity - EPC-synthesis