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Synthesis 1997; 1997(8): 863-865
DOI: 10.1055/s-1997-1274
short paper
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A Convenient and Efficient Synthesis of (2S,4R)- and (2S,4S)-4-Methylglutamic Acid

Elisabeth Coudert, Francine Acher* , Robert Azerad
  • *Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Université René Descartes-Paris V, 45 Rue des Saints-Pères, 75270 Parix Cedex 06, France, Fax +33(0)142860402; E-mail: acher@bisance.citi2.fr
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Publication History

Publication Date:
31 December 2000 (online)

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Both enantiomerically pure (2S,4S)- and (2S,4R)-4-methylglutamic acids have been prepared in an overall 60% yield, by a convenient 7-step synthesis based on C-4 alkylation/epimerization of readily available (S)-pyroglutamic acid.

pyroglutamic acid - 4-methylglutamic acid - Bredereck's reagent - ion exchange chromatography - glutamate receptors