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Synthesis 1997; 1997(8): 891-894
DOI: 10.1055/s-1997-1280
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Facile and Efficient Deoxygenation of Aromatic N-Oxides with Zinc and Aqueous Ammonium Chloride

Yutaka Aoyagi, Tomomitsu Abe, Akihiro Ohta*
  • *School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, Fax +81(426)763040
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Publication History

Publication Date:
31 December 2000 (online)

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Several aromatic N-oxides such as pyrazine, arylpyridine and quinoline N-oxides have been deoxygenated to parent amines under mild and efficient conditions using zinc and aqueous ammonium chloride in tetrahydrofuran.

zinc - ammonium chloride - deoxygenation - aromatic N-oxide - pyrazine N-oxide