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Synthesis 1997; 1997(8): 874-876
DOI: 10.1055/s-1997-1285
short paper
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Synthesis of Alkynyl Ketones via Palladium- and Copper-Catalyzed Carbonylative Cross Coupling of Iodonium Salts with Alk-1-ynes

Suk-Ku Kang* , Kwon-Ho Lim, Pil-Su Ho, Won-Yeob Kim
  • *Department of Chemistry, Sung Kyun Kwan University, Natural Science Campus, Suwon 440-746, Korea, Fax +82(331)2907074; E-mail: skkdng@chem.skku.ac.kr
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Publication Date:
31 December 2000 (online)

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The palladium- and copper-catalyzed coupling of iodonium salts with alk-1-ynes in the presence of atmospheric pressure of carbon monoxide in DME/H2O (4:1) and Pd(OAc)2 (0.2 mol%) [or Pd(OAc)2 with CuI (10 mol%) and NaHCO3 (1.2 equiv)], or CuI (10 mol%) and NaHCO3 (2.2. equiv) at 30°C afforded α,β-acetylenic ketones.

palladium-catalyzed carbonylative cross coupling - iodonium salts - copper-catalyzed carbonylative coupling