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DOI: 10.1055/s-1999-13504
Hippokrates Verlag Stuttgart
Experimental Use of Prosthetic Grafts in Microvascular Surgery
Experimentelle Anwendung von synthetischen Prothesen in der mikrovaskulären ChirurgiePublication History
31.10.1998
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/hamipla/199902/lookinside/thumbnails/10.1055-s-1999-13504-1.jpg)
Zusammenfassung
Synthetische Mikrogefäßinterponate zur Überbrückung von Gefäßdefekten wären hilfreich in der Wiederherstellungschirurgie. Wir untersuchten im Tierexperiment das Verhalten von Polytetrafluoroethylen(PTFE)-Interponaten im Vergleich zu autologen Venentransplantaten. PTFE-Prothesen von 1 mm Innendurchmesser und 10 mm Länge wurden in die Arteria femoralis des Kaninchens implantiert. Die Durchgängigkeit wurde mit der Doppier-Methode kontrolliert und alle Prothesen histologisch untersucht. Die Durchgängigkeitsrate der synthetischen Prothesen war nach vier Wochen mit 25% wesentlich niedriger (p < 0,0001) als in der autologen Kontrollgruppe.
Abstract
Interpositional microvascular grafts are very often required in reconstructive surgery for bridging microvascular defects, particularly in association with replantation of amputated segments and free tissue transplantation. The present experimental study was undertaken to evaluate patency and healing of small-diameter polytetrafluoroethylene (PTFE) prostheses and to compare them with those of microvenous grafts. 10-mm long micro-arterial PTFE grafts of 1 mm internal diameter were implanted into the femoral artery of the rabbit to restore vascular continuity. Patency was assessed by Doppier ultrasound up to four weeks postoperatively. After harvesting, all grafts were evaluated macroscopically and examined by light and transmission electron microscopy. According to our results, five of 20 re-explored PTFE grafts (25%) remained patent at four weeks, while all microvenous grafts were judged to be patent at the same time. The difference between patency rates was found to be statistically significant (p < 0.0001). Recent literature on the experimental use of microvascular prostheses is reviewed and various factors affecting graft patency are discussed.
Schlüsselwörter
Mikrochirurgie - Venentransplantate - Mikrogefäßprothesen - Intima-Hyperplasie -
Key words
Microsurgery - microvenous grafts - microvascular prostheses - intimal hyperplasia