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Synthesis 2001(5): 0773-0777
DOI: 10.1055/s-2001-12766
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Synthetic Approach for the Preparation of Rigid Analogs of 1,3-Dipropyl-7-methyl-8-aryl/heteroarylstyryl Xanthines

Pier Giovanni Baraldi*, Abdel Zaid Nasser, Francesca Fruttarolo, Mojgan Aghazadeh Tabrizi, Maria del Carmen Nuñez, Giampiero Spalluto, Romeo Romagnoli
Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 17/19, 44100 Ferrara, Italy
Fax: +39(532)291296; e-Mail: pgb@dns.unife.it;
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Publication History

Received 20 November 2000
Publication Date:
15 October 2004 (online)

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Abstract

Tethering the N-8-substituents of N-8-substituted styryl xanthine to N-7 has resulted in a series of conformationally constrained styryl xanthine analogs having the general formula 8. These new compounds have also been evaluated in order to investigate if the A2A adenosine receptor would be able to tolerate such a modification.

Key words

styryl xanthines - photoisomerization - A2A adenosine receptor antagonists - conformationally constrained analogues

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