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Synthesis 2001(5): 0702-0704
DOI: 10.1055/s-2001-12778
DOI: 10.1055/s-2001-12778
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A Facile Synthesis of a (±)-2,3-Disubstituted Maleic Anhydride Segment of Tautomycin [1]
Further Information
Received
2 December 2000
Publication Date:
15 October 2004 (online)
Publication History
Publication Date:
15 October 2004 (online)
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Abstract
A convenient method for construction of a (±)-2,3-disubstituted maleic anhydride segment of antibiotic tautomycin is reported. The key steps involved in the synthesis are chemoselective condensation of diethyl malonate with 2-(bromomethyl)-3-methylmaleic anhydride (3) and regioselective NBS-bromination of the maleic anhydride derivative 7.
Key words
Tautomycin - antifungal antibiotic - regioselective NBS-bromination - part structure synthesis
NCL Communication No. 6605.
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References
NCL Communication No. 6605.