Augmented Acute Normovolemic Hemodilution (A-ANH^TM) in Cardiac and Non-Cardiac Patients

Key words:

Hemodilution - Surgery - Blood transfusion - Perfluorocarbons - Blood Sparing

References

• 1 Habler O, Messmer K. Avoidance of allogeneic transfusion in surgery.  Anaesthesist. 1997;  46 915-926
• 2 AuBouchon J P, Birkmeyer J D, Busch M P. Cost effectiveness of expanded human immunodefficiency virus-testing protocols for donated blood.  Transfusion. 1997;  37 45-51
• 3 Faithfull N S. Mechanisms and efficacy of fluorochemical oxygen transport and delivery.  Artif Cells Blood Subst Immobil Biotechnol. 1992;  20 603-609
• 4 Zuck T F, Riess J G. Current status of injectable oxygen carrierrs.  Crit Rev Clin Lab Sci. 1994;  31 295-324
• 5 Leese P T, Noveck R J, Shorr J S, Woods C M, Flaim K E, Keipert P E. Randomized safety studies of intravenous perflubron emulsion I. Effects on coagulation function in healthy volunteers.  Anesth Analg. 2000;  91 801-804
• 6 Noveck R J, Shannon E J, Leese P T, Shorr J S, Flaim K E, Keipert P E, Woods C M. Randomized safety studies of intravenous perflubron emulsion II. Effects on immune function in healthy volunteers.  Anesth Analg. 2000;  91 812-822
• 7 Habler O P, Kleen M S, Hutter J W, Podtschaske A H, Tiede M, Kemming G I, Welte M V, Corso C O, Batra S, Keipert P E, Faithfull N S, Messmer K. Hemodilution and intravenous perflubron emulsion as analternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs.  Transfusion. 1998;  38 144-155
• 8 Wahr J A, Trouwborst A, Spence R K, Henny C P, Cernaianu A C, Graziano G P, Tremper K K, Flaim K E, Keipert P E, Faithfull N S, Clymer J J. A pilot study of the effects of a perflubron emulsion.  Anesth Analg. 1996;  82 103-107
• 9 Spahn D R, van Bremt R, Theilmeier G, Reibold J -P, Welte M, Heinzerling H, Birck K, Keipert P E, Messmer K, the European Perflubron Emulsion Study Group. Perflubron emulsion delays blood transfusion in orthopedic surgery.  Anesthesiology. 1999;  91 1195-2108
• 10 Monk T, Winston R, Wahr J, Frei D, Wang J, Keipert P, for the Perflubron Emulsion Study Group. Perflubron Emulsion is more effective than blood for transfusion trigger reversal.  Anesth Analg. 1998;  86 S 1-S 551
• 11 Spahn D, Waschke T, Standl T, Motsch J, Welte M, Vanhuynegem L, Gombotz H, Coirat P, Keipert P, the Oxygent Study Group. Oxygent TM reduces allogeneic blood transfusions in noncardiac surgery: a Phase 3 study.  Eur J Anesth. 2001;  18 58