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Synthesis 2001(16): 2393-2396
DOI: 10.1055/s-2001-18705
DOI: 10.1055/s-2001-18705
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of 1-Substituted 5-Aminoimidazole-4-carbaldehydes and 8-Amino-1-(2-fluorobenzyl)imidazo[4’,5’:5,6]pyrido[2,3-d]pyrimidine
Further Information
Received
27 July 2001
Publication Date:
05 August 2004 (online)
Publication History
Publication Date:
05 August 2004 (online)
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Abstract
The syntheses of a number of 1-substituted 5-aminoimidazole-4-carbaldehydes 3, by the reduction of the corresponding 5-amino-4-cyanoimidazole derivatives is reported using LiAlH(OEt)3, prepared in situ from LiAlH4 and ethyl acetate. The compounds of type 1 are useful intermediates for the synthesis of elongated adenine derivatives.
Key words
heterocycles - imidazoles - cyanides - aldehydes - imidazo[4’,5’:5,6]pyrido[2,3-d]pyrimidines
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