PDF herunterladen
Aktuelle Rheumatologie 2002; 27(3): 138-146
DOI: 10.1055/s-2002-33133
Originalarbeit
© Georg Thieme Verlag Stuttgart · New York

Parvovirus B19- und Togavirus-assoziierte Arthritiden

Parvovirus B19 and Togavirus-associated ArthritisAnke  Praast1 , A.  Krause1
  • 1Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitätsklinikum Charité und Rheumaklinik Berlin-Wannsee, Berlin
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
05. August 2002 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Zusammenfassung

Zahlreiche Viren können akute und auch chronisch verlaufende Arthritiden auslösen oder auch andere entzündliche Gelenkerkrankungen in ihrem Verlauf beeinflussen. Neben den in eigenen Artikeln dieses Heftes behandelten Hepatitisviren und dem HIV sind hier insbesondere das humane Parvovirus B19 sowie die Familie der Togaviren mit dem Rötelnvirus sowie verschiedene Alphaviren zu nennen. Erwähnenswert, obwohl von untergeordneter Bedeutung, sind zudem die Erreger von Masern und Mumps. In dem Artikel werden Pathogenese, klinische Symptomatik und Diagnostik der von diesen Viren hervorgerufenen rheumatologischen Krankheitsbilder im Einzelnen besprochen.

Abstract

Several viruses are able to cause acute and chronic arthritides or may influence the clinical course of other inflammatory rheumatic diseases. Besides hepatitis viruses and HIV which will be discussed in other articles of this journal, parvovirus B19 and the members of the family of togaviridae, rubella virus and alpha viruses, are of special rheumatologic interest. Noteworthy, although less important, are arthritides caused by measles and mumps viruses. In this article, we describe the pathogenesis, clinical picture, and diagnosis of the rheumatologic syndromes caused by these viruses.

Literatur

  • 1 Altschuler E L. Parvovirus B19 and the pathogenesis of rheumatoid arthritis: a case for historical reasoning.  Lancet. 1999;  354 1026-1027
    CrossrefPubMedGoogle Scholar
  • 2 Anderson M J, Higgins P G, Davis L R. Experimental parvoviral infection in humans.  J Infect Dis. 1985;  152 257-265
    PubMedGoogle Scholar
  • 3 Bengtsson A, Widell A, Elmstahl S. et al . No serologic indications that systemic lupus erythematosus is linked with exposure to human parvovirus B19.  Ann Rheum Dis. 2000;  59 64-66
    CrossrefPubMedGoogle Scholar
  • 4 Benjamin C M, Chew G C, Silman A J. Joint and limb symptoms in children after immunization with measles, mumps and rubella vaccine.  BMJ. 1992;  304 1075-1078
    PubMedGoogle Scholar
  • 5 Bosma T J, Etherington J, Best J M. Rubella virus and chronic joint disease: Is there an association?.  J clin Microbiol. 1998;  36 3524-3526
    PubMedGoogle Scholar
  • 6 Cassinotti P, Bas S, Siegl G, Vischer T L. Association between human parvovirus B19 infection and arthritis.  Ann Rheum Dis. 1995;  54 498-500
    PubMedGoogle Scholar
  • 7 Chang Y N, Kenan D J, Keene J D, Gatignol A, Jeang K T. Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.  J Virol. 1994;  68 7008-7020
    PubMedGoogle Scholar
  • 8 Chantler J K, Ford D K, Tingle A J. Persistent rubella infection and rubella-associated arthritis.  Lancet. 1982;  8285 1323-1325
    PubMedGoogle Scholar
  • 9 Fawaz-Estrup F. Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus.  J Rheumatol. 1996;  23 1180-1185
    PubMedGoogle Scholar
  • 10 Fraser J RE, Cunningham A L, Hayes K, Leach R, Lunt R. Rubella arthritis in adults: Isolation of virus, cytology and other aspects of the synovial reaction.  Clin Exp Rheumatol. 1983;  1 287
    PubMedGoogle Scholar
  • 11 Frenkel L M, Nielson K, Cherry J D. et al . A search for persistent rubella virus infection in persons with chronic symptoms after rubella and rubella immunization and in patients with juvenile rheumatoid arthritis.  Clin Infect Dis. 1996;  22 287-294
    PubMedGoogle Scholar
  • 12 Gendi N ST, Gibson K, Wordsworth B P. Effect of HLA type and hypocomplementemia on the expression of parvovirus arthritis: one year follow-up of an outbreak.  Ann Rheum Dis. 1996;  55 63-65
    PubMedGoogle Scholar
  • 13 Hahn H, Falk D, Kaufmann S HE, Ullmann U (Hrsg). Medizinische Mikrobiologie und Infektiologie. 4. Auflage. Springer-Verlag 2001
    Google Scholar
  • 14 Harley D, Sleigh A, Ritchie S. Ross river virus transmission, infection, and disease.  Clin Microbiol Rev. 2001;  14 909-932
    CrossrefPubMedGoogle Scholar
  • 15 Howson C P, Howe C J, Fineberg H V. Adverse effects of pertussis and rubella vaccines: a report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines. Devision of health promotion and disease prevention. Institute of Medicine, National Academy Press 1991
    Google Scholar
  • 16 Hsu T C, Tsay G J. Human parvovirus B19 infection in patients with systemic lupus erythematosus.  Rheumatology. 2001;  40 152-157
    PubMedGoogle Scholar
  • 17 Huppertz H I. How could infectious agents hide in synovial cells? Possible mechanisms of persistent viral infection in a model for the etiopathogenesis of chronic arthritis.  Rheumatol Int. 1994;  14 71-75
    CrossrefPubMedGoogle Scholar
  • 18 Ilonen J, Salmi A. Comparison of HLA-Dw1 and -Dw2 positive adherent cells in antigen presentation to heterozygous T-cell lines: a low rubella antigen-specific response associated with HLA-Dw2.  Human Immunol. 1986;  17 94-101
    PubMedGoogle Scholar
  • 19 Kato S, Muranaka S, Takakura I, Kimura M, Tsuji K. HLA-DR antigens and the rubella-specific immune response in man.  Tissue Antigens. 1982;  19 140-145
    PubMedGoogle Scholar
  • 20 Kelley W N, Harris E D, Ruddy S, Sledge C B. Textbook of Rheumatology. 5th Edition. Philadelphia, Pennsylvania; WB Saunders Company 1997: 2
    Google Scholar
  • 21 Kerr J R, Cartron J P, Curran M D. et al . A study of the role of parvovirus B19 in rheumatoid arthritis.  Br J Rheumatol. 1995;  34 809-813
    PubMedGoogle Scholar
  • 22 Kerr J R. Pathogenesis of human parvovirus B19 in rheumatic diseases.  Ann Rheum Dis. 2000;  59 672-683
    CrossrefPubMedGoogle Scholar
  • 23 Köhler W, Eggers H J, Fleischer B, Marre R, Pfister H, Pulverer G (Hrsg). Medizinische Mikrobiologie. 8. Auflage. München/Jena Urban & Fischer 2001
    Google Scholar
  • 24 Laine M, Luukkainen R, Jalava J, Ilonen J, Kuusistö P, Toivanen A. Prolonged arthritis associated with Sindbis-related (Pogosta) virus infection.  Rheumatology. 2000;  19 1272-1274
    PubMedGoogle Scholar
  • 25 Lio D, Caccamo N, D'Anna C, Cigna D, Candore G, Caruso C. Viral antibody titers are influenced by HLA-DR2 phenotype.  Exp Clin Immunogenet. 1994;  11 182-186
    PubMedGoogle Scholar
  • 26 Lunardi C, Tiso M, Borgota L. et al . Chronic parvovirus B19 infection induces the production of antibodies with autoantigen binding properties.  Eur J Immunol. 1998;  28 936-948
    CrossrefPubMedGoogle Scholar
  • 27 Mitchell L A, Tingle A J, Grace M, Middleton P, Chalmers A C. Rubella virus vaccine associated arthropathy in postpartum immunized women: Influence of preimmunization serologic status on development of joint manifestations.  J Rheumatol. 2000;  27 418-423
    PubMedGoogle Scholar
  • 28 Mitchell L A, Tingle A J, MacWilliam L, Horne C, Keown P, Gaur L K, Nepom G T. HLA-DR class II associations with rubella vaccine-induced joint manifestations.  J Infectious Dis. 1998;  177 5-12
    PubMedGoogle Scholar
  • 29 Mitchell L A, Tingle A J, Shukin R, Sangeorzan J A, McCune J, Braun D K. Chronic rubella vaccine-associated arthropathy.  Arch Intern Med. 1993;  153 2268
    CrossrefPubMedGoogle Scholar
  • 30 Moore T L, Bandlamudi R, Alam S M. et al . Parvovirus infection mimicking systemic lupus erythematosus in a pediatric population.  Semin Arthritis Rheum. 1999;  28 314-318
    CrossrefPubMedGoogle Scholar
  • 31 Moore T L. Parvovirus-associated arthritis.  Curr Opin Rheumatol. 2000;  12 289-294
    CrossrefPubMedGoogle Scholar
  • 32 Murai C, Munakata Y, Takahashi U. et al . Rheumatoid arthritis after human parvovirus B19 infection.  Ann Rheum Dis. 1999;  58 130-132
    PubMedGoogle Scholar
  • 33 Murray P R, Baron E J, Pfaller M A, Tenover F C, Yolken R H. Manual of Clinical Microbiology. 7th Edition. American Society for Microbiology 1999
    Google Scholar
  • 34 Nakhasi H L, Singh N K, Pogue G P, Cao X Q, Rouault T A. Identification and characterization of host factor interactions with cis-acting elements of rubella virus RNA.  Arch Virol. 1994;  9 255-267
    PubMedGoogle Scholar
  • 35 Nesher G, Moore T L. Human parvovirus infection.  Infect Med. 1997;  14 638-642
    PubMedGoogle Scholar
  • 36 Nesher G, Osborn T G, Moore T L. Parvovirus infection mimicking systemic lupus erythematosus.  Semin Arthritis Rheum. 1995;  24 297-303
    CrossrefPubMedGoogle Scholar
  • 37 Nussinoviten M, Harel L, Varsano I. Arthritis after mumps and measles vaccination.  Arch Dis Child. 1995;  72 348-349
    PubMedGoogle Scholar
  • 38 Peltola H, Heinonen O P, Valle M. The elimination of indigenous measles, mumps and rubella from Finland by a 12-year, two-dose vaccination program.  N Engl J Med. 1994;  331 1397-1402
    CrossrefPubMedGoogle Scholar
  • 39 Phillips P E. Viral arthritis.  Curr Opin Rheumatol. 1997;  9 337-344
    PubMedGoogle Scholar
  • 40 Pogue G P, Hofmann J, Duncan R, Best J M, Etherington J, Sontheimer R D, Nakhasi L. Autoantigens interact with cis-acting elements of rubella virus RNA.  J Virol. 1996;  70 6269-6277
    PubMedGoogle Scholar
  • 41 Pogue G P, Cao X Q, Singh N K, Nakhasi H L. 5'sequences of rubella virus RNA stimulate translation of chimeric RNAs and specifically interact with two host-encoded proteins.  J Virol. 1993;  67 7106-7117
    PubMedGoogle Scholar
  • 42 Polk B F, Modlin J F, White J A, di Girolami P C. A controlled comparison of joint reactions among women receiving one of two rubella vaccines.  Am J Epidemiol. 1982;  115 19-25
    PubMedGoogle Scholar
  • 43 Powers A M, Brault A C, Shirako Y, Strauss E G, Kang W, Strauss J H, Weavers S C. Evolutionary relationships and systematics of the alphaviruses.  J Virol. 2001;  75 10 118-10 131
    PubMedGoogle Scholar
  • 44 Ray P, Black S, Shinefield J, Dillon A, Schwalbe J, Holmes S, Hadler S, Chen R, Cochi S, Wassilak S. Risk of chronic arthropathy among women after rubella vaccination.  JAMA. 1997;  278 551-556
    CrossrefPubMedGoogle Scholar
  • 45 Salmi A A. Measles Virus. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (Eds) Manual of Clinical Microbiology. 7th Edition 73. American Society for Microbiology 1999: 951-957
    Google Scholar
  • 46 Schnitzer T J, Penmetcha M. Viral Arthritis.  Curr Opinion Rheumatol. 1996;  8 341-345
    PubMedGoogle Scholar
  • 47 Slater P E, Ben-Zvi T, Fogel A, Ehrenfeld M, Ever-Hadani S. Absence of an association between rubella vaccination and arthritis in underimmune postpartum women.  Vaccine. 1995;  13 1529-1532
    CrossrefPubMedGoogle Scholar
  • 48 Soderlund M, von Essen R, Haapasaari J. et al . Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy.  Lancet. 1997;  349 1063-1065
    CrossrefPubMedGoogle Scholar
  • 49 Speyer I, Breedveld F C, Dijkmans B AC. Human parvovirus B19 infection is not followed by inflammatory joint disease during long-term follow-up: a retrospective study of 54 patients.  Clin Exp Rheumatol. 1998;  16 576-578
    PubMedGoogle Scholar
  • 50 Stahl H D, Seidl B, Hubner B. et al . High incidence of parvovirus B19 DNA in synovial tissue of patients with undifferentiated mono- and oligoarthritis.  Clin Rheumatol. 2000;  19 281-286
    CrossrefPubMedGoogle Scholar
  • 51 Takahashi Y, Murai C, Shibata S. et al . Human parvovirus B19 as a causative agent for rheumatoid arthritis.  Proc Natl Acad Sci USA. 1998;  95 8227-8232
    CrossrefPubMedGoogle Scholar
  • 52 Tingle A J, Allen M, Petty R E, Kettyls G D, Chantler J K. Rubella-associated arthritis: comparative study of joint manifestations associated with natural rubella infection and RA27/3 rubella immunisation.  Ann Rheum Dis. 1986;  45 110-114
    PubMedGoogle Scholar
  • 53 Tingle A J, Chantler J K, Pot K H, Paty D W, Ford D K. Postpartum rubella immunization: association with development of prolonged arthritis, neurological sequelae, and chronic rubella viremia.  J Infect Dis. 1985;  152 606-612
    PubMedGoogle Scholar
  • 54 Tingle A J, Mitchell L A, Grace M, Middleton P, Mathias R, MacWilliam L, Chalmers A. Randomised double-blind placebo-controlled study on adverse effects of rubella immunisation in seronegative woman.  Lancet. 1997;  349 1277-1281
    CrossrefPubMedGoogle Scholar
  • 55 Trapani S, Ermini M, Falcini F. Human parvovirus B19 infection: its relation with systemic lupus erythematosus.  Semin Arthritis Rheum. 1999;  28 319-325
    CrossrefPubMedGoogle Scholar
  • 56 Turunen M, Kuusisto P, Uggeldahl P E, Toivanen A. Pogosta disease: clinical observations during an outbreak in the province of North Karelia, Finland.  Br J Rheumatol. 1998;  37 1177-1180
    CrossrefPubMedGoogle Scholar
  • 57 Weibel R E, Benor D E. Chronic arthropathy and musculoskeletal symptoms associated with rubella vaccines. A review of 124 claims submitted to the national vaccine injury compensation program.  Arthritis & Rheumatism. 1996;  39 1529-1534
    PubMedGoogle Scholar
  • 58 Woolf A D, Cohen B J. Parvovirus B19 and chronic arthritis: causal or casual association?.  Ann Rheum Dis. 1995;  54 535-536
    PubMedGoogle Scholar
  • 59 Ytterberg S R. Viral arthritis.  Curr Opin Rheumatol. 1999;  11 275-280
    CrossrefPubMedGoogle Scholar
  • 60 Zhang D, Nikkari S, Vainionpaa R, Luukkainen R, Yli-Kerttula U, Toivanen P. Detection of rubella, mumps, and measles virus genomic RNA in cells from synovial fluid and peripheral blood in early rheumatoid arthritis.  J Rheumatol. 1997;  24 1260-1265
    PubMedGoogle Scholar

Prof. Dr. A. Krause

Rheumaklinik Berlin-Wannsee · Immanuelkrankenhaus GmbH

Königstraße 63 · 14109 Berlin

Telefon: (030) 80505 292

Fax: (030) 80505 299

eMail: a.krause@immanuel.de

      >