Titanium(IV) Chloride-Mediated Ortho-Acylation of Phenols and Naphthols

Abstract

The use of titanium(IV) chloride as a Lewis acid for direct ortho-acylation of phenols and naphthols proves to be a convenient, more general and direct route to various hydroxyaryl ketones. The route is regioselective, leading to ortho C-acylated products in satisfactory to high yields in most cases.

Key words

ortho-acylation - Lewis acid - electrophilic substitution - hydroxyaryl ketone - regioselectivity

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