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Viszeralchirurgie 2003; 38(6): 366-373
DOI: 10.1055/s-2003-45504
Originalarbeit
© Georg Thieme Verlag Stuttgart · New York

Präoperative Diagnostik bei gastrointestinalen Stromatumoren

Preoperative Diagnostic Procedures in Gastrointestinal Stromal TumorsJ.  Schütte1 , G.  Antoch2
  • 1Klinik für Onkologie/Hämatologie, Marien Hospital Düsseldorf, Düsseldorf
  • 2Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Essen
Further Information

Publication History

Publication Date:
15 December 2003 (online)

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Zusammenfassung

Die präoperative Diagnostik gastrointestinaler Stromatumoren (GIST) zur Bestimmung der Tumorausdehnung und der Resektabilität entspricht weitgehend der Diagnostik anderer Tumoren des Gastrointestinaltrakts. Komplexer ist die bildgebende Verlaufsbeobachtung des Therapieansprechens während einer präoperativen Induktionstherapie mit Imatinib bei primär nicht im Gesunden resektablen GIST. Die Positronenemissionstomographie (PET) ist derzeit die Methode der Wahl, um ein (funktionelles) Therapieansprechen frühzeitig und mit hoher Genauigkeit erkennen zu können, ist aber nur eingeschränkt verfügbar. Computertomographisch ermittelte (morphologische) Surrogatparameter scheinen mit dem PET-Ansprechen zu korrelieren, bedürfen jedoch noch der Validierung in prospektiven Studien.

Abstract

Preoperative diagnostic procedures in patients with gastrointestinal stromal tumors (GIST) for the assessment of tumor exten-sion and resectability resemble the diagnostic of other gastrointestinal tumors. More challenging, however, is the evaluation of treatment response during preoperative induction therapy with imatinib in patients with primarily irresectable GIST. Positron emission tomography (PET) is the diagnostic tool of choice with a high sensitivity and specifity for the evaluation of treatment response but is not readily available. Alternatively, computed tomography (CT) may provide surrogate parameters which correlate well with the PET response but require further evaluation in prospective studies.

Schlüsselwörter

Gastrointestinale Stromatumoren - GIST - Diagnostik - Computertomographie - PET

Key words

Gastrointestinal stromal tumor - GIST - diagnosis - computed tomography - PET

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Prof. Dr. J. Schütte

Klinik für Onkologie/Hämatologie, Marien Hospital Düsseldorf, Interdisziplinäres Onkologisches Zentrum

Rochusstraße 2

40479 Düsseldorf

Phone: + 49-211-4400-2501

Fax: + 49-211-4400-2210

Email: jochen.schuette@uni-essen.de