Aktuelle Rheumatologie 2004; 29(1): 40-49
DOI: 10.1055/s-2004-812963
Originalarbeit
© Georg Thieme Verlag Stuttgart · New York

Bekannte und neue therapeutische Konzepte der Behandlung der Psoriasis und der Arthritis psoriatica

Well-Known and New Therapeutic Concepts of Psoriasis and Psoriatic ArthritisC. Tomiak1 , W. Miehle1
  • 1Klinik Wendelstein der BfA, Rheumazentrum AHB
Further Information

Publication History

Publication Date:
21 September 2005 (online)

Zusammenfassung

Die Arthritis psoriatica (A. ps.) fristete lange Zeit ein „Mauerblümchendasein”. Die Bestrebungen, sie als eigene nosologische Entität anzuerkennen, verliefen schleppend und sind letztlich bis heute nicht abgeschlossen. Angesiedelt zwischen chronischer Polyarthritis (Synonym: rheumatoide Arthritis) und den Spondarthritiden sucht die überwiegend mit charakteristischen Hautveränderungen einhergehende chronische Arthritis noch ihren Platz. Die mögliche polyarthritische Verlaufsform sowie Wirbelsäulenmanifestationen und Enthesitiden bilden Gemeinsamkeiten mit den beiden häufigsten rheumatologischen Krankheitsbildern. Alle Bemühungen um ein stichhaltiges therapeutisches Konzept erfolgten bisher „im Windschatten” der chronischen Polyarthritis (c. P.) und der Psoriasis. Zusätzlich erschwerend erscheint, dass die ärztliche Zuständigkeit für die Erkrankung oft nicht eindeutig geklärt ist, was z. B. auch an den unterschiedlichen Bezeichnungen abzulesen ist: Der Dermatologe spricht von der Osteoarthropathia psoriatica oder Psoriasis arthropathica, der Rheumatologe von der Psoriasisarthritis oder Arthritis psoriatica. Internistische Rheumatologen verwenden bevorzugt die Bezeichnung Arthritis psoriatica, da Zeichen der Gelenkentzündung das Krankheitsbild charakterisieren.

Abstract

For a long time, psoriatic arthritis had a “wallflower existence.” Efforts to recognize the disease as a distinct nosologic entity were slow in progress and are still not completed. Allocated somewhere between rheumatoid arthritis and spondyloarthropathies, this disease, which is predominantly associated with characteristic skin lesions, is still searching for its true place. It shares the potential polyarthritic course, axial skeletal involvement and enthesopathic manifestation with both of the most frequent inflammatory rheumatic diseases. All therapeutic concepts were derived from those established in treating rheumatoid arthritis and psoriasis. The search for its place is hampered further by the fact that the right medical specialist is often not consulted. This also reflects the inconsistent terminology: the dermatologist calls it osteoarthritis psoriatica or arthropathic psoriasis and the rheumatologist psoriatic arthritis. As internal medicine-oriented rheumatologists, we prefer the term arthritis psoriatica (psoriasis arthritis) since the arthritic inflammation characterize the clinical manifestation of this disease.

Literatur

  • 1 Abu-Shakra M, Gladman D D, Thorne J C. et al . Longterm methotrexate therapy in psoriatic arthritis: clinical and radiological outcome.  J. Rheumatol. 1995;  22 (2) 241-245
  • 2 Antoni C, Kavannaugh A, Kirkham B. et al . The infliximab multinational psoriatic arthritis controlled trial (IMPACT).  Arthritis Rheum. 2002;  46 (985) 381
  • 3 Antoni C, Kavanaugh A, Kirkham B. et al . The one year results of Infliximab Multinational Psoriatic Arthritis Controlled Trial (IMPACT).  ACR. 2003;  10 Abstract S265-S266
  • 4 Brockbank J, Gladman D D. Diagnosis and Management of Psoriatic Arthritis.  Drugs. 2002;  62 (17) 2447-2457
  • 5 Cañete J D, Sanmarti R, Marsal S. et al . Antiangiogenic effects of infliximab in synovial tissue in psoriatic arthritis.  ACR. 2003;  10 Abstract S170
  • 6 Cauza E, Spak M, Cauza K. et al . Treatment of psoriatic arthritis and psoriasis vulgaris with the tumor necrosis factor inhibitor infliximab.  Rheumatol Int. 2002;  22 227-232
  • 7 Chang D J. A survey of drug effektveness and treatment choices in psoriatic arthritis (Abstr.).  Arthritis Rheum. 1999;  42 (Suppl. 9) 372
  • 8 Clegg D, Reda D J, Mejias E. et al . Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis. A Department of Veterans Affairs Cooperative study.  Arthritis Rheum. 1996;  39 (12) 2013-2020
  • 9 Combe B, Goupille P, Kuntz J L. et al . Sulphasalazine in psoriatic arthritis: A randomized, multicentre, placebo-controlled study.  Br J Rheumatol. 1996;  35 664-668
  • 10 Dougados M, van der Linden S, Juhlin R. et al . The European Spondylarthropathy Study Group preliminary criteria for the classification of spondyloarthropathy.  Arthritis Rheum. 1991;  34 1218-1227
  • 11 Elkayam O, Ophir J, Brener S. et al . Immediate and delayed effects of treatment at the Dead Sea in patients with psoriatic arthritis.  Rheumatol Int. 2000;  19 77-82
  • 12 Ellis C N, Krueger G G. for the Alefacept Clinical Study Group . Treatment of chronic plaque psoriasis by selective targetting of memory effector T-Lymphocytes.  N Engl J Med. 2001;  345 248-255
  • 13 Enghard P, Riemekaste G. Regulatorische T-Zellen - ein mögliches Ziel zur Behandlung von systemischen Autoimmunkrankheiten.  Z Rheumatol. 2003;  6 355-360
  • 14 Farr M, Kitas G D, Waterhouse L. et al . Sulphasalazine in psoriatic arthritis: a double blind placebo controlled study.  Br J Rheum. 1990;  24 46-49
  • 15 Felson D T, Anderson J J, Boers M. et al . Americal College of Rheumatology preliminary definitiions of improvement in rheumatoid arthritis.  Arthritis Rheum. 1995;  38 727-735
  • 16 Fischer M, Modder G. Radionuclidetherapy of inflammatory joint disease (Abstract).  Nucl Med Commun. 2002;  23 829-831
  • 17 Fournie B, Crognier L, Arnaud C. et al . Proposed classification criteria of psoriatic arthritis: a preliminary study in 260 patients.  Revue Du Rhumatisme, English edition. 1999;  66 446-456
  • 18 Fraser A D, van Kuryk A, Westhovens R. et al . A randomise, double-blind, placebo controlled multi-centre trial of combination therapy with methotrexat plus Ciclosporin vs. Mehtotrexat plus placebo in patients with active psoriatic arthritis (PsA).  ACR. 2003;  10 Abstract 170
  • 19 Fredriksson T, Pettersson U. Severe psoriasis: Oral therapy with a new retinoid.  Dermatologica. 1978;  157 238-244
  • 20 Geilen C C, Amold M, Orfanos C E. Mycophenolate mofetil as a systemic antipsoriatic agent: positive experience in II patients.  Br J Dermatol. 2001;  144 583-586
  • 21 Gladman D D, Farewell V T. Progression in psoriatic arthritis: role of time varying clinical indicators.  J Rheumatol. 1999;  26 2409-2413
  • 22 Gladman D D, Hing E N, Schentag C T. et al . Remission in psoriatic arthritis.  J Rheumatol. 2001;  28 (5) 1045-1048
  • 23 Gladman D D. Effectiveness of psoriatic arthritis therapies.  Semin Arthritis Rheum. 2003;  33 29-37
  • 24 Goedkoop A Y, de Rie M A, Kraan M G. et al . Alefacept treatment in psoriatic arthritis: dinical improvement of sldn lesions and arthritis correlates with reduction in CD45RO + T cells in epidermis and synovial tissue.  Br J Dermatol. 2002;  147 1073
  • 25 Gorman J D, Kenneth E S, Davis J C. Treatment of ankylosing spondylitis by inhibition of tumor necorsis factor α.  N Engl J Med. 2002;  346 1349
  • 26 Gottlieb A B, Vaishnaw A K. Alefacept (Amevive) does not blunt primary or secondary immune responses.  Arthritis Rheum. 2002;  44 S91
  • 27 Granstein R D. New treatments for psoriasis.  N Engl J Med. 2001;  345 284-287
  • 28 Grundman-Kollman M, Mooser G, Schraeder P. et al . Treatment of chronic plaque-stage psoriasis and psoriatic arthritis with mycophenolate mofetil.  J Am Acad Dermatol. 2000;  42 835-837
  • 29 Gupta A K, Grober J S, Hamilton T A. et al . Sulfasalazine therapy for psoriatic arthritis: a double blind, placebo controlled triaI.  J Rheumatol. 1996;  23 (4) 791-792
  • 30 Heyendal V, Spuls P I, Opmeer B C. et al . Methotrexate versus Cyclosporine in Moderate-to-severe chronic plaque psoriasis.  N Engl J Med. 2003;  349 658-665
  • 31 Huscher D, Thiele K, Listing J. et al . The German Collaborative Arthritis Centres, German Rheumatism Research Centre, Berlin: Burden of illness and treatment in psoriatic arthritis compared to rheumatoid arthritis and ankylosing spondylitis in Germany.  ACR. 2003;  10 Abstract 610
  • 32 Husted J A, Gladman D D, Farewell V T. Health-related quality of life of patients with psoriatic arthritis: a comparison with patients with rheumatoid arthritis.  Arthritis Care & Research. 2001;  45 151-158
  • 33 Husted J, Farewell V, Schentag C T. et al . Changing functional status in patients with psoriatic arthritis: a multistate model approach.  ACR. 2003;  10 Abstract S171
  • 34 Jeannou I P, Goupille M. et al . Cervical spine involvement in psoriatic arthritis.  Rev Rhum (Engl. Ed). 1999;  66 (12) 695-700
  • 35 Jones S M, Armas J, Cohen M. et al . Psoriatic arthritis: outcome of disease subsets and relationship of joint disease to nail and skin disease.  Br J Rheumatol. 1994;  33 834-839
  • 36 Jung G. Dermatologie;. Duale Reihe. 4. Auflage Stuttgart; Hippokrates 1998: 377 ff
  • 37 Kaltwasser P, Nash P, Gladman D. et al . Leflunomide in the treatment of psoriatic arthritis and psoriasis: Data from a double-blind, randomized, Plazebocontrolled Clinical trial.  Ann Rheum Dis. 2003;  62 (Suppl I) OP 0081-S90
  • 38 Kane D, Stefford L, Bresnihan B. et al . A classification study of clinical subsets in an inception cohort with early psoriatic peripheral arthritis: DIP or not DIP revisited.  Rheumatology. 2003;  6 1676-1685
  • 39 Kirby B, Fortune D G. et al . The Salford Psoriasis Index: an holistic measure of psoriasis.  Br J Dermatol. 2000;  142 728-732
  • 40 Kirby B, Richards H L. et al . Physical and psychological measures are necessary to assess overall psoriasis severity.  J Am Acad Dermatol. 2001;  45 72-76
  • 41 Klinkhoff A, Maksymowych W, Mosher D. et al . The clinical assessement of patients with psoriatica arthritis (PsA): Results of a validation study of the Spondyloarthritis Research Consortium of Canada (SPARCC).  ACR. 2003;  10 Abstract S168
  • 42 Krueger J, Kikuchi T, Chamian F. et al . Alefacept selectively targets effector memory and type I T cells, but spares central memory and naive populations.  Br J Dermatol. 2002;  147 1062
  • 43 Krueger G, Vaishnaw A K. 987 alefacept (human LFA-3/lgG I fusion protein) is non-immunogenic in two randomized, placebo-controlled phase III trials for chronic plaque psoriasis.  J Allergy Clin Immunol. 2002;  109 320
  • 44 Lacaille D, Stein H B, Raboud J. et al . Longterm therapy of psoriatic arthritis: intramuscular gold or methotrexate?.  J Rheumatol. 2000;  27 1922-1927
  • 45 Laiho K, Kauppi M. The cervical spine in patients with psoriatic arthritis.  Ann Rheum Dis. 2002;  61 650-652
  • 46 Lebwohl M, Tyring S K, Hamilton T K. et al . A Novel Target T-Cell Modulator Efalizumab, for Plaque Psoriasis.  N Engl J Med. 2003;  349 2004-2013
  • 47 Lewis J S, Ravindran J S, Korendowych E. et al . Prevalence and characteristics of undiagnosed psoriatic arthropathy in psoriasis: a challenge for genetic studies.  Br J Dermatol. 2002;  147 1047-1078
  • 48 Lewis J S, Ravindran J S, Lovell C. et al . Quiesent sacroiliitis within a psoriatic population.  ACR. 2003;  10 Abstract S170
  • 49 Liang G C, Barr W G. Leflunomide for refractory psoriasis and psoriatic arthritis.  J Clin Rheumat. 2001;  7 366-370
  • 50 Marguerie L, Flipo R M, Grardel B. et al . Use of disease-modifying anti-rheumatic drugs in patients with psoriatic arthritis.  Bone Spine. 2002;  60 275-281
  • 51 Mazzani G, Colini L, DeSabbata G. et al . Methotrexate and cyclosporine combined therapy in severe psoriatic arthritis. A pilot study.  Acta Dermatomyositis Venereol Suppl (Stockh.). 1994;  186 116-117
  • 52 McGonagle D, Conaghan P G, Emery P. Psoriatic arthritis: a unified concept twenty years on.  Arthritis Rheum. 1999;  42 1080-1086
  • 53 Mease P. Etanercept in the treatment of psoriatic arthritis and psoriasis; Power point presentation. www.medscape/com/viewprogramm/256_pnt
  • 54 Mease P, Nash P, Gladman D. et al . Leflunomide in the treatment of psoriatic arthritis and psoriasis; joint and skin efficacy and safety in the TOPAS Study.  ACR. 2003;  10 Abstract S169
  • 55 Menter A, Evans R, Dooley L T. et al . Infliximab improves signs of plaque psoriasis in patients with psoriatic arthritis.  ACR. 2003;  10 Abstract S168
  • 56 Miehle W. Medikamentöse Therapie rheumatischer Erkrankungen. Stuttgart/New York; Thieme 2003
  • 57 Miehle W. Arthritis psoriatika. Rheumamed Samerberg 2003
  • 58 Ogilvie A L, Antoni C, Dechant C. et al . Treatment of psoriatic arthritis with antitumor necrosis factor-alpha antibody dears skin lesions of psoriasis resistant to treatment with methotrexate.  Br J Dermatol. 2001;  144 (3) 587-589
  • 59 Ohtsuki M, Nakagawa H, Sugai J. et al . Long-term contrinuous versus intermittent cyclosporin therapy for psoriasis.  Dermatol. 2003;  30 290-298
  • 60 Olivieri I, Salvarani C, Cantini F. et al . Therapy with cyclosporine in psoriatic arthritis.  Semin Arthritis Rheum. 1997;  27 36-43
  • 61 Pigatto P D, Gibelli E, Ranza R. et al . Methotrexate in psoriatic polyarthritis.  Acta Derm. Venereol. 1994;  186 (Suppl.) lI4-lI5
  • 62 Punzi L, Pianon M, Bertazzolo N. et al . Clinical, laboratory and immunogenetic aspects of posttraumatic psoriatic arthritis: a study of 25 patients.  Clinical and Experimental Rheumatology. 1998;  16 (3) 277-281
  • 63 Queiro-Silva R, Torre-Alonso J C, Tinture-Eguren T. et al . A polyarticular onset predicts erosive and deforming disease in psoriatic arthritis.  Ann Rheum Dis. 2003;  62 (I) 68-70
  • 64 Raffayova H, Rovensky J, Malis F. Treatment with cyclosporine in patients with psoriatic arthritis: results of clinical assessment.  Int J Clin Pharmacol Res. 2000;  20 I-lI
  • 65 Savarani C, Cantini F, Olivieri I. et al . Efficacy of infliximab in resistant psoriatic arthritis.  Arthritis Rheum. 2003;  49 541-545
  • 66 Schräder P, Maser G, Peter R U. et al . Erste Ergebnisse der Therapie der Psoriasisarthritis mit Mycophenolatmofetil.  Z Rheumatol. 2002;  61 545-550
  • 67 Sparado A, Riccieri V, Sili-Scavalli A. et al . Comparison of cyclosporin A and methotrexate in the treatment of psoriatic arthritis: a one-year prospective study.  Clin Exp Rheumatol. 1997;  13 (5) 589-593
  • 68 Spuls P I, Bossuyt P MM, van Everdingen J JE. et al . The developement of practice guidelines for the treatment fo severe plaque form psoriasis.  Arch Dermatol. 1998;  134 1591-1596
  • 69 Tak P P, Maarten C K, Goedkoop A Y. et al . Alefacept therapy reduces the number of effector/memory T cells in psoriasis lesional epidermis.  ACR. 2003;  10 Abstract S168
  • 70 Takada K, Dannig C L, Juroiwa T. et al . Lymphocyte depletion with fludarabine in patients with psoriatic arthritis: clinical and immunological effects.  Ann Rheum Dis. 2003;  62 1112-1115
  • 71 Timonen P, Fried D, Abeywickrama K. et al . Efficacy of low-dose cyclosporin A in psoriasis: results of dosefinding studies.  Br J Dermatol. 1990;  122 33-39
  • 72 Ujfalussy I, K06 E, Sesztak M. et al . Termination of disease-modifying antirheumatic drugs in rheumatoid arthritis and in psoriatic arthritis.  Z Rheumatol. 2003;  62 155-160

OA Dr. med. C. Tomiak

Klinik Wendelstein der BfA, Rheumazentrum AHB

Kolbermoorer Straße 56

83043 Bad Aibling

Email: klinik-wendelstein@t-online.de

    >