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DOI: 10.1055/s-2006-956763
© Georg Thieme Verlag Stuttgart · New York
Schmerzen bei Parkinson-Syndrom
Pain in Parkinson's DiseasePublication History
Publication Date:
09 November 2006 (online)
Parkinsonpatienten klagen sehr häufig über Schmerzen und Missempfindungen. Dennoch werden Schmerzen bei Parkinsonpatienten häufig unterschätzt, fehldiagnostiziert und -behandelt. Opiate können die Parkinson-Symptomatik verschlechtern und Verwirrtheitszustände hervorrufen. Das therapeutische Vorgehen zielt zunächst auf eine Optimierung der dopaminergen Medikation, da Schmerzen meist mit der Akinese, dem Rigor, zusammenhängen und mit motorischen Fluktuationen korrelieren. In einem weiteren Schritt kommt ein multimodaler Therapieansatz mit Analgetika, Physiotherapie und psychoedukativen Maßnahmen zur Anwendung.
Pain and sensory complaints are common among Parkinson's disease patients. Despite its high prevalence in Parkinson's disease the burden of pain is often underestimated, misdiagnosed and not appropriately treated. Opioids can exacerbate rigidity and produce confusional states. Therapeutic strategies should firstly aim at a sufficient dopaminergic stimulation since pain is frequently linked to akinesia, rigidity and may fluctuate similarly to motor signs. Secondly, a multimodal approach including analgesics, physiotherapy and psychoeducation is frequently helpful to avoid chronification and impaired quality of life.
Key Words
pain - Parkinson's disease - parkinsonism
Literatur
- 1 Boecker H, Ceballos-Baumann AO, Weindl A, Bartenstein P, Siebner H, Faßbender T, Munz F, Schwaiger M, Conrad B. A PET activation study of sensory processing in Parkinson's disease and Huntington's disease. Brain. 1999; 122 1651-65
- 2 Born LJ, Harned RH, Rikkers LF, Pfeiffer RF, Quigley EM. Cricopharyngeal dysfunction in Parkinson's disease: role in dysphagia and response to myotomy. Mov Disord. 1996; 11 53-8
- 3 Brefel-Courbon C, Payoux P, Thalamas C, Ory F, Quelven I, Chollet F, Montastruc JL, Rascol O. Effect of levodopa on pain threshold in Parkinson's disease: a clinical and positron emission tomography study. Mov Disord. 2005; 20 1557-63
- 4 Bushmann M, Dobmeyer SM, Leeker L, Perlmutter JS. Swallowing abnormalities and their response to treatment in Parkinson's disease. Neurology. 1989; 39 1309-14
- 5 Cantello R, Aguggia M, Gilli M, Delsedime M, Riccio A, Rainero I, Mutani R. Analgesic action of methylphenidate on parkinsonian sensory symptoms. Mechanisms and pathophysiological implications. Arch Neurol. 1988; 45 973-6
- 6 Ceballos-Baumann A, Gündel H. Bewegungsstörungen. In: Henningsen P, Gündel H, Ceballos-Baumann A, editors. Neuropsychosomatik. Stuttgart: Schattauer 2006
- 7 Ceballos-Baumann AO. Idiopathisches Parkinson-Syndrom: Grundlagen, Medikamente, Therapieeinleitung. In: Ceballos-Baumann AO, Conrad B (edts.). Bewegungsstörungen in der Neurologie. 2 überarbeitete Auflage Stuttgart, Thieme 2005: 33-70
- 8 Decina P, Mukherjee S, Caracci G, Harrison K. Painful sensory symptoms in neuroleptic-induced extrapyramidal syndromes. Am J Psychiatry. 1992; 149 1075-80
- 9 Edwards LL, Quigley EM, Harned RK, Hofman R, Pfeiffer RF. Defecatory function in Parkinson's disease: response to apomorphine. Ann Neurol. 1993; 33 490-3
- 10 Ford B. Pain in Parkinson's disease. Clin Neurosci. 1998; 5 63-72
- 11 Ford B, Louis ED, Greene P, Fahn S. Oral and genital pain syndromes in Parkinson's disease. Mov Disord. 1996; 11 421-6
- 12 Goetz CG, Tanner CM, Levy M, Wilson RS, Garron DC. Pain in Parkinson's disease. Mov Disord. 1986; 1 45-9
- 13 Grazko MA, Polo KB, Jabbari B. Botulinum toxin A for spasticity, muscle spasms, and rigidity. Neurology. 1995; 45 712-7
- 14 Indaco A, Carrieri PB. Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study. Neurology. 1988; 38 1720-2
- 15 Mathers SE, Kempster PA, Swash M, Lees AJ. Constipation and paradoxical puborectalis contraction in anismus and Parkinson's disease: a dystonic phenomenon?. J Neurol Neurosurg Psychiatry. 1988; 51 1503-7
- 16 Pacchetti C, Albani G, Martignoni E, Godi L, Alfonsi E, Nappi G. „Off” painful dystonia in Parkinson's disease treated with botulinum toxin. Mov Disord. 1995; 10 333-6
- 17 Polo KB, Jabbari B. Botulinum toxin - A improves the rigidity of progressive supranuclear palsy. Ann Neurol. 1994; 35 237-9
- 18 Putzki N, Maschke M, Drepper J, Diener HC, Timmann D. Effect of functional NMDA-antagonist flupirtine on automatic postural responses in Parkinson's disease. J Neurol. 2002; 249 824-8
- 19 Riley D, Lang AE, Blair RDG, Birnbaum A, Reid B. Frozen shoulder and other shoulder abnormalities in Parkinson's disease. J Neurol Neurosurg Psych. 1988; 52 63-66
- 20 Schmidt WJ, Schuster G, Wacker E, Pergande G. Antiparkinsonian and other motor effects of flupirtine alone and in combination with dopaminergic drugs. Eur J Pharmacol. 1997; 327 1-9
- 21 Schott GD. Pain in Parkinson's disease. Pain. 1985; 22 407-11
- 22 Schwarz M, Nolden-Koch M, Purr J, Pergande G, Block F. Antiparkinsonian effect of flupirtine in monoamine-depleted rats. J Neural Transm Gen Sect. 1996; 103 581-90
- 23 Snider SR, Fahn S, Isgreen WP, Cote LJ. Primary sensory symptoms in parkinsonism. Neurology. 1976; 26 423-9
- 24 Starkstein SE, Preziosi TJ, Robinson RG. Sleep disorders, pain, and depression in Parkinson's disease. Eur Neurol. 1991; 31 352-5
- 25 Tinazzi M, Del C Vesco, Fincati E, Ottaviani S, Smania N, Moretto G, Fiaschi A, Martino D, Defazio G. Pain and motor complications in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2006; 77 822-5
- 26 Tison F, Wiart L, Guatterie M, Fouillet N, Lozano V, Henry P, Barat M. Effects of central dopaminergic stimulation by apomorphine on swallowing disorders in Parkinson's disease. Mov Disord. 1996; 11 729-32
- 27 Vanek Z, Jankovic J. Dystonia in corticobasal degeneration. Mov Disord. 2001; 16 252-7
Korrespondenzadresse:
Dr. Arda Yazici
Facharzt für Anästhesiologie, Spezielle Schmerztherapie
Sendlinger Str. 19
80331 München
Email: ayazici@web.de
Prof. Dr. Andres Ceballos-Baumann
Neurologisches Krankenhaus München
Tristanstr. 20
80804 München
Email: andres.ceballos-baumann@nk-m.de