Download PDF
Planta Med 1998; 64(2): 116-119
DOI: 10.1055/s-2006-957386
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Preliminary Study of the Potential Vasodilator Effects on Rat Aorta of Centaurein and Centaureidin, Two Flavonoids from Centaurea corcubionensis

F. Orallo1 , M. Lamela1 , M. Camiña1 , E. Uriate2 , J. M. Calleja1
  • 1Departamento de Farmacología, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
  • 2Departamento de Química Orgánica, Facultad de Farmacia. Universidad de Santiago de Compostela, Spain
Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

In this work, the potential vasorelaxant activity of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis, were studied for the first time in rat aorta. Centaureidin (10 µM-0.1 mM) totally relaxed, in a concentration-dependent manner and with almost equal effectiveness, the contractions induced by NA (IC50 = 16.7 ± 1.9 µM) or by a high K+ concentration (IC50 = 16.1 ± 3.1 µM) in intact rat aortic rings. Mechanical removal of endothelium did not significantly modify the vasoralexant effects of this flavone (IC50 = 20.8 ± 2.4 µM for NA; IC50 = 21 ± 2.9 µM for K+). On the other hand, centaurein (1 µM-0.1 mM) had no effect on NA- and high K+-induced contractions in rubbed and intact rat aortic rings. These results indicate that substitution by glucose in the chemical structure of centaureidin leads to the loss of its vasodilator activity.

Key words

Centaurea corcubionensis - Asteraceae - centaurein - centaureidin - vasodilator effects - rat aorta