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Horm Metab Res 1991; 23(7): 333-335
DOI: 10.1055/s-2007-1003690
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Insulin Clearance During Hypoglycemia in Patients with Insulin-Dependent Diabetes Mellitus

M. Kollind1 , E. Moberg1 , D. Liu2 , P.-E. Lins1 , U. Adamson1
  • 1Department of Internal Medicine, Danderyd Hospital, Stockholm, Sweden
  • 2Department of Endocrinology, Peking Union Medical College Hospital, Peking, China
Further Information

Publication History

1990

1990

Publication Date:
14 March 2008 (online)

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Summary

Eight male patients with insulin-dependent diabetes mellitus (IDDM) without residual beta-cell function were studied on two occasions in random order. In one experiment hypoglycemia was induced by a constant rate iv infusion of insulin (0.034 U/kg/h) during 150 minutes. At the other occasion an identical infusion of insulin was given, but this time euglycemia was maintained by a variable iv infusion of glucose. Plasma levels of free insulin were almost identical during the two experiments indicating that insulin clearance is not influenced by hypoglycemia in patients with IDDM.

Key words

Diabetes Mellitus - Hypoglycemia - Insulin Clearance