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Horm Metab Res 1991; 23(7): 341-343
DOI: 10.1055/s-2007-1003692
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Lack of Modulation of the Adrenocortical Response to ACTH by an Opioid Peptide

T. A. Howlett, A. Grossman, A. Froud, L. Perry1 , G. M. Besser
  • Department of Endocrinology, St. Bartholomew's Hospital, London, England
  • 1Department of Reproductive Physiology, St. Bartholomew's Hospital, London, England
Further Information

Publication History

1990

1991

Publication Date:
14 March 2008 (online)

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Summary

Eight normal male subjects received 1 mg dexamethasone at 23.00 h and 0.5 mg on wakening followed by a physiological intravenous dose of synthetic ACTH1-24250 ng, with and without the administration of a stable met-enkephalin analogue (guanyl-DAMME, 100 μg) 10 minutes prior to the ACTH. The opioid analogue caused no change in the peak, incremental, or incremental area under the curve responses of plasma cortisol to the ACTH. This study does not support a role for opioid peptides in the acute modulation of the adreno-cortical response to ACTH.

Key words

Opioid - Adrenal - Cortisol - ACTH