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Horm Metab Res 1991; 23(9): 438-441
DOI: 10.1055/s-2007-1003721
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Intraindividual Variation of Beta2-Adrenergic Receptors on Mononuclear Leukocytes and Their Relationships with Endogenous Plasma Catecholamines in Man

A. Pende, N. R. Musso, C. Vergassola, A. Ioverno, G. Galbariggi, G. Lotti
  • Patologia Medica R, Istituto Scientifico di Medicina Interna, Università degli Studi di Genova, Ospedale S. Martino, Genoa, Italy
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Publication History

1990

1991

Publication Date:
14 March 2008 (online)

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Summary

The interindividual and intraindividual variations of both MNL beta2-adrenergic receptor density and dissociation constant of binding were evaluated in 19 healthy volunteers. In addition the possible relationships between catecholamine plasma levels and MNL beta2-adrenergic receptor density were studied in 8 of these subjects.

The volunteers were studied three times with ten days' interval.

There was a significant inverse relationship between receptor density and norepinephrine plasma levels, only. Neither epinephrine nor dopamine were correlated with receptor density.

Interindividual coefficient of variation was 29.57%. The mean value of the intraindividual coefficients of variation was 14.1%, while the mean value of the analytical coefficients of variation was 10%.

Our results are at some variance with data in the literature and may contribute to elucidate the role of MNL beta2-adrenergic receptors as an index of sympathetic function in man.

Key words

Beta2-Adrenergic Receptors - Mononuclear Leukocytes - Norepinephrine - Epinephrine - Dopamine - Catecholamines