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Horm Metab Res 1988; 20(11): 705-708
DOI: 10.1055/s-2007-1010922
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Human Atrial Natriuretic Polypeptide in Plasma of Patients with Anorexia Nervosa

M. Ohashi1 , N. Fujio1 , H. Nawata1 , K. Kato1 , S. Matsubayashi2 , H. Tamai2 , H. Matsuo3 , H. Ibayashi1
  • 1Third Department of Internal Medicine, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • 2Department of Psychosomatic Medicine, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • 3Second Department of Biochemistry, Miyazaki Medical College, Miyazaki, Japan
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Publication History

1987

1987

Publication Date:
14 March 2008 (online)

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Summary

To examine the effects of chronic dehydration and starvation on plasma levels of human atrial natriuretic polypeptide (hANP) in human subjects, the basal level and saline-induced rise of plasma hANP in 7 patients with anorexia nervosa were compared with those in age-matched healthy subjects. The unstimulated level of plasma hANP was markedly high in the patients with anorexia nervosa (patients vs. control; 55.4±9.0 pg/ml vs. 11.4±6.1 pg/ml, P < 0.01). However, no significant increase of plasma hANP in the anorectic patients was observed in response to saline-infusion, while a 3-fold increase over the basal level of plasma hANP was noted in the saline-infused normal young subjects. These results show that hANP may be secreted to an inadequate extent, hence the release would be resistant to volume-loading. The pathophysiological meaning of such a high plasma concentrations of hANP in anorexia nervosa is the subject of ongoing studies.

Key-Words

Weight Loss - RIA - Dehydration - Saline