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Horm Metab Res 1987; 19(10): 478-480
DOI: 10.1055/s-2007-1011857
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© Georg Thieme Verlag, Stuttgart · New York

Hyperresponsiveness of Residual Thyroid Lobe of Hemithyroidectomised Rat to Thyrotropin

L. K. Malendowicz
  • Department of Histology and Embryology, Poznań Academy of Medicine, Poznań, Poland
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Publication History

1986

1987

Publication Date:
14 March 2008 (online)

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Summary

The effects of hemithyroidectomy and thyrotropin administration on rat thyroid gland function were studied in adult male rats. Immediately after surgery or sham operation rats were treated daily with 0.12 IU of bovine thyrotropin (TSH) for 3 or 5 days.

In control rats TSH dose applied resulted in an increase in serum T4 level at day 5 of experiment. Serum thyroxine concentration markedly decreased in sham operated and hemithyroidectomised rats, an effect observed at days 3 and 5 of experiment. TSH administration had no effect on serum T4 concentration in sham operated rats while in hemithyroidectomised animals such a treatment resulted in a marked increase in serum T4 level, a phenomenon observed in both time intervals studied.

The reasons for hemithyroidectomy-induced hyperresponsiveness of rat thyroid residual lobe to thyrotropin are unknown.

Key-Words

Rat - Hemithyroidectomy - TSH - Hyperresponsiveness to TSH - Thyroid Hormones