Formation of β-Substituted γ-Keto Esters via Zinc Carbenoid Mediated Chain Extension

Abstract

The conversion of β-keto esters into β-methylated γ-keto esters can be achieved through treatment with zinc carbenoids derived­ from 1,1-diiodoethane. The incorporation of a β-phenyl substituent is also possible through treatment with diiodotoluene.

Key Words

carbenoids - diiodoethane - esters - chain extension - zinc

References

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5

Pu, Q., unpublished results, University of New Hampshire.