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Planta Med 1986; 52(2): 77-79
DOI: 10.1055/s-2007-969083
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© Georg Thieme Verlag Stuttgart · New York

Isoputrin and Butrin, the Antihepatotoxic Principles of Butea monosperma Flowers1

Hildebert Wagner2 , Bettina Geyer2 , Manfred Fiebig2 , Yoshinobu Kiso3 , Hiroshi Hikino3
  • 2Institute of Pharmaceutical Biology, University of Munich, Karlstr. 29, D-8000 Munich 2, Federal Republic of Germany
  • 3Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
1 Part 12 in the University of Munich series on “drugs for liver therapy” (H. Wagner), Part 30 in the Tohoku University series on “liver-protective drugs” (H. Hikino)
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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

Since an extract from the flowers of Butea monosperma, a plant drug used in India for the treatment of liver disorders, showed significant activity in different models of liver damage, the extract was fractionated by solvent partitioning and HPLC, and activity monitored by means of CCl4- and GalN-induced liver lesion in vitro. The antihepatotoxic principles isolated consisted of two known flavonoids, isobutrin (3, 4, 2′, 4′-tetrahydroxychalcone-3, 4′-diglucoside), and the less active butrin (7, 3′, 4′-trihydroxyflavanone-7, 3′-diglucoside). For qualitative and quantitative analysis of isobutrin and butrin in extracts of Butea monosperma flowers a HPLC system was developed.