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Synthesis 2008(16): 2582-2588  
DOI: 10.1055/s-2008-1067192
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© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 3-Indolylarylmethanamides by Samarium Triiodide Catalyzed Friedel-Crafts Amidoalkylation

Hui Mao, Xiaoxia Wang*, Wencun Wang, Liang He, Lichun Kong, Junhua Liu
Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, P. R. of China
Fax: +86(579)82282595; e-Mail: wangxiaoxia@zjnu.cn;
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Publication History

Received 31 January 2008
Publication Date:
24 July 2008 (online)

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Abstract

The amidoalkylation of indoles with N-(α-benzotriazol-1-ylalkyl)amides was smoothly realized with samarium triiodide as a catalyst to give a series of novel 3-indolyl arylmethanamides with good yields and selectivities.

Key words

amidoalkylation - N-(α-benzotriazol-1-ylalkyl)amides - indoles - samarium triiodide - catalysis